L. Lan

An end-to-end workflow for non-destructive 3D pathology

This paper provides an end-to-end workflow for non-destructive 3D pathology using light-sheet microscopy, focusing on fluorescent H&E analogs for preclinical and clinical studies.

Video-rate Mid-infrared Photothermal Imaging by Single Pulse Photothermal Detection per Pixel

This paper introduces a single pulse photothermal microscope for video-rate mid-infrared imaging, enabling observation of lipid dynamics and mapping fat storage in living systems.

Rationally designed inhibitors of the Musashi protein-RNA interaction by hotspot mimicry

This paper designs inhibitors for Musashi proteins MSI1 and MSI2 by mimicking hotspot pharmacophores from protein-RNA complexes, showing specificity and activity in multiple assays.

Wireless Neuromodulation at Submillimeter Precision via a Microwave Split-Ring Resonator

This paper introduces a microwave split-ring resonator that enables submillimeter precision neuromodulation by enhancing microwave field localization and efficiency for inhibiting neurons.

USP28 deletion and small molecule inhibition destabilises c-Myc and elicits regression of squamous cell lung carcinoma

This study shows that deleting or inhibiting USP28 reduces c-Myc levels and causes regression of lung squamous cell carcinoma in mice and human xenografts.

Mechanism of RNA recognition by a Musashi RNA-binding protein

This study uses GaMD simulations to elucidate the dynamic mechanism of Numb RNA binding to MSI1, providing insights for drug design targeting this interaction.

A novel copper-sensing two-component system for activating Dsb genes in bacteria

The paper identifies a novel copper-sensing two-component system, DsbRS, in Pseudomonas aeruginosa that activates the dsbDEG operon involved in copper resistance.

RNA-Binding Proteins MSI-1 (Musashi) and EXC-7 (HuR) Regulate Serotonin-Mediated Behaviors in C. elegans

The paper shows MSI-1 and EXC-7 regulate serotonin-mediated mating behaviors in C. elegans by stabilizing mRNA of a G protein and affecting serotonin synthase activity.