NLRP1 inflammasome modulates senescence and senescence-associated secretory phenotype
I. Muela-Zarzuela, J. M. Suarez-Rivero, A. Gallardo-Orihuela, C. Wang, K. Izawa, M. de Gregorio-Procopio, I. Couillin, B. Ryffel, J. Kitaura, A. Sanz, T. von Zglinicki, G. Mbalaviele, M. D. Cordero
This study shows that NLRP1 inflammasome promotes senescence and SASP through GSDMD-dependent regulation of p16, p21, p53, and SASP expression.
bioRxiv · Feb 6, 2023 · PreprintImmunology