TLR7/8 stress response drives histiocytosis in SLC29A3 disorders
K. Miyake, T. Shibata, R. Sato, M. Taoka, S.-I. Saitoh, M. Komine, K. Yamaguchi, S. Goyama, Y. Motoi, J. Kitaura, K. Izawa, Y. Yamauchi, Y. Tsukamoto, T. Ichinohe, E. Fujita, , T. Taguchi
This study identifies TLR7/8 as drivers of histiocytosis in SLC29A3 disorders by responding to lysosomal nucleoside stress and enhancing monocyte proliferation and phagocyte maturation.
bioRxiv · Oct 27, 2022Immunology