S. Goyama

The paper identifies lineage-specific therapeutic vulnerabilities in AML subtypes using a two-group comparison approach based on genetic data from the Cancer Dependency Map.

This study identifies TLR7/8 as drivers of histiocytosis in SLC29A3 disorders by responding to lysosomal nucleoside stress and enhancing monocyte proliferation and phagocyte maturation.

This study identifies PLXDC2 as a marker for isolating hematopoietic stem cells (HSCs) in both mouse and human, showing its utility in transplantation and xenograft models.

The paper identifies MECOM as a critical regulator that suppresses acinar cell death by enabling dedifferentiation under stress conditions in both human and mouse models.

This study shows PRDM3 suppresses pancreatitis and pancreatic tumorigenesis by modulating inflammation and Kras-driven oncogenesis in acinar cells.