Author

J. L. Perry

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Microbiology· 7 Evolutionary Biology· 1

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 3 Organism:human· 2 Assay:imaging· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

J. M. Hyser· 5 shared A. C. Strtak· 3 shared A. L. Chang-Graham· 2 shared I. Burd· 2 shared J. Lei· 2 shared K. A. Engevik· 2 shared M. K. Estes· 2 shared P. S. Creisher· 2 shared

Activity by Year

2017-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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5 shared papersMicrobiology

J. M. Hyser

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Author profile →

8 papers

Recent·Most cited

Suppression of progesterone by influenza A virus mediates adverse maternal and fetal outcomes in mice

P. S. Creisher, M. A. Parish, J. Lei, J. Liu, J. L. Perry, A. D. Campbell, M. L. Sherer, I. Burd, S. L. Klein

This study shows that influenza A virus suppresses progesterone in pregnant mice, leading to adverse maternal and fetal outcomes, which can be mitigated by progestin treatment.

bioRxiv · Sep 11, 2023Microbiology

The Inositol Trisphosphate Receptor (IP3R) is Dispensable for Rotavirus-induced Ca2+ Signaling and Replication but Critical for Paracrine Ca2+ Signals that Prime Uninfected Cells for Rapid Virus Spread

J. L. Perry, F. J. Scribano, J. T. Gebert, K. A. Engevik, J. M. Ellis, J. M. Hyser

This study shows that IP3R is dispensable for rotavirus replication in infected cells but critical for intercellular Ca2+ waves that prime uninfected cells for virus spread.

bioRxiv · Aug 9, 2023 · PreprintMicrobiology

Adverse outcomes in SARS-CoV-2 infected pregnant mice are gestational age-dependent and resolve with antiviral treatment

P. S. Creisher, J. L. Perry, W. Zhong, J. Lei, K. R. Mulka, H. Ryan, R. Zhou, E. H. Akin, A. Liu, W. Mitzner, I. Burd, A. Pekosz, S. L. Klein

This study shows that SARS-CoV-2 infection in pregnant mice causes worse outcomes at later gestational ages, which can be improved with antiviral treatment.

bioRxiv · Mar 23, 2023Microbiology

Rotavirus Induces Intercellular Calcium Waves Through ADP Signaling

A. C. Chang-Graham, J. L. Perry, M. A. Engevik, H. A. Danhof, F. Scribano, K. A. Engevik, J. Nelson, J. S. Kellen, A. C. Strtak, N. S. Palla, M. K. Estes, J. Versalovic, R. A. Britton, J. M. Hyser

This study shows rotavirus induces intercellular calcium waves via ADP signaling, which amplifies diarrheal symptoms and can be blocked by P2Y1 antagonists or knockout.

bioRxiv · Dec 31, 2019Microbiology

Generation of Recombinant Rotavirus Expressing NSP3-UnaG Fusion Protein by a Simplified Reverse Genetics System

A. Philip, J. L. Perry, H. Eaton, M. Shmulevitz, J. M. Hyser, J. Patton

This paper generates a recombinant rotavirus with a genetically modified segment 7 dsRNA encoding NSP3-UnaG fusion protein, showing efficient replication and enhanced detection compared to NSP1-based FPs.

bioRxiv · Oct 2, 2019Microbiology

Recovirus NS1-2 has viroporin activity that induces aberrant cellular calcium signaling to facilitate virus replication

A. C. Strtak, J. L. Perry, M. N. Sharp, A. L. Chang-Graham, T. Farkas, J. M. Hyser

This study identifies the NS1-2 protein of Tulane virus as a viroporin that disrupts calcium homeostasis, facilitating virus replication by altering cellular calcium signaling.

bioRxiv · Jul 16, 2019Microbiology

Rotavirus Calcium Dysregulation Manifests as Dynamic Calcium Signaling in the Cytoplasm and Endoplasmic Reticulum

A. L. Chang-Graham, J. L. Perry, A. C. Strtak, N. K. Ramachandran, J. M. Criglar, A. A. Philip, J. T. Patton, M. K. Estes, J. M. Hyser

This study characterizes dynamic calcium signaling during rotavirus infection, showing increased cytosolic calcium spikes and ER release, with NSP4 and SOCE playing key roles.

bioRxiv · May 6, 2019Microbiology

Silversword and lobeliad reintroduction linked to landscape restoration on Mauna Loa and Kilauea, and its implications for plant adaptive radiation in Hawaii

R. H. Robichaux, P. Y. Moriyasu, J. H. Enoka, S. McDaniel, R. K. Loh, K. F. Bio, A. Bakutis, J. T. Tunison, S. T. Bergfeld, J. L. Perry, F. R. Warshauer, M. Wasser, T. C. Cole, N. R. Agorastos, I. W. Cole, , M. M. Bruegmann

This paper describes reintroduction efforts for endangered silversword and lobeliad species in Hawaii Volcanoes National Park, linked to landscape restoration to support population growth and potential adaptive radiation.

Biological Conservation · Sep 1, 2017Peer-reviewedEvolutionary Biology