M. K. Estes

This study shows that BA-dependent human norovirus strains require S1PR2 for infection, while BA-independent strains do not, suggesting S1PR2 as a potential therapeutic target.

The paper investigates E. coli strains from cancer patients with diarrhea, finding novel adherence patterns and high antibiotic resistance gene carriage.

The paper studies intra- and inter-host evolution of human norovirus in healthy adults using a capture-based sequencing approach, finding limited conserved immune pressure-driven evolution.

This study tests nitazoxanide's antiviral activity against human noroviruses using a standardized pipeline in human intestinal enteroids, finding no significant antiviral effect.

This study compares infant and adult human intestinal enteroids, finding significant transcriptomic, morphological, and functional differences that highlight their distinct characteristics.

This study demonstrates that hepatobiliary organoids from leporids support replication of hepatotropic lagoviruses, with species-specific tropism observed in different host organoids.

This study evaluates heat inactivation of human norovirus in freshwater clams using human intestinal enteroids, finding that 1 minute at 90°C inactivates the virus.

This study uses human ileal enteroid-derived monolayers to show that Yersinia pseudotuberculosis YopE prevents uptake by M cells and causes their extrusion, facilitating bacterial transcytosis.

This paper develops a non-invasive human nose organoid model to study RSV and SARS-CoV-2 infection and test therapeutics like palivizumab.

This study identifies dasabuvir as an anti-HuNoV inhibitor using human intestinal enteroids, showing activity against HuNoV, SARS-CoV-2, and RVA.

This paper optimizes human intestinal enteroid culture conditions to enhance cultivation of diverse human norovirus strains and improves replication consistency over time.

This study shows that coronin 1a is required for M cell uptake and transcytosis of pathogens in human ileal enteroids, but not commensal bacteria.

This paper establishes a protocol for isolating and maintaining rabbit intestinal organoids and monolayers, demonstrating their ability to mimic intestinal epithelium and support pathogen research.

The paper identifies obesity-related phenotypes in intestinal stem cell enteroids from morbidly obese patients and shows they retain patient-specific traits post-bariatric surgery.

This study shows rotavirus induces intercellular calcium waves via ADP signaling, which amplifies diarrheal symptoms and can be blocked by P2Y1 antagonists or knockout.

This study characterizes dynamic calcium signaling during rotavirus infection, showing increased cytosolic calcium spikes and ER release, with NSP4 and SOCE playing key roles.

This paper develops a method to increase enteroendocrine cells in human intestinal enteroids using inducible neurogenin-3 expression, enabling functional studies of gut hormone secretion.

This paper introduces a co-culture system to study host-microbe interactions under physiological hypoxia using human intestinal enteroids and anaerobic bacteria.

This study shows bile acids like DCA alter lipid nano-assemblies in the plasma membrane, promoting EGFR clustering and MAPK signaling in Caco-2 cells and human intestinal enteroids.