S. L. Klein

ZFAND6 is a subunit of a TRAF2-cIAP E3 ubiquitin ligase complex essential for mitophagy

This study identifies ZFAND6 as a component of a TRAF2-cIAP E3 ubiquitin ligase complex that regulates mitophagy, maintaining mitochondrial homeostasis and influencing immune responses to viral infection.

Estradiol Mediates Greater Germinal Center Responses to Influenza Vaccination in Female than Male Mice

This study shows estradiol enhances germinal center responses and antibody production in female mice after influenza vaccination, leading to better protection against viral challenge.

Suppression of progesterone by influenza A virus mediates adverse maternal and fetal outcomes in mice

This study shows that influenza A virus suppresses progesterone in pregnant mice, leading to adverse maternal and fetal outcomes, which can be mitigated by progestin treatment.

Adverse outcomes in SARS-CoV-2 infected pregnant mice are gestational age-dependent and resolve with antiviral treatment

This study shows that SARS-CoV-2 infection in pregnant mice causes worse outcomes at later gestational ages, which can be improved with antiviral treatment.

Greater breadth of vaccine-induced immunity in females than males is mediated by increased antibody diversity in germinal center B cells

This study shows that female mice have stronger and more diverse antibody responses to influenza vaccination, leading to better protection against mutant viruses due to increased germinal center B cell activity.

A bacterial extracellular vesicle-based intranasal vaccine against SARS-CoV-2 protects against disease and elicits neutralizing antibodies to wild-type virus and Delta variant

Progression and Resolution of SARS-1 CoV-2 Infection in Golden Syrian Hamsters

This study tracks SARS-CoV-2 infection progression in golden Syrian hamsters, showing weight loss, lung damage, and resolution over time.

Sex differences in lung imaging and SARS-CoV-2 antibody responses in a COVID-19 golden Syrian hamster model

This study shows that male golden Syrian hamsters experience more severe lung disease and lower antiviral antibody responses compared to females after SARS-CoV-2 infection.