Author

J. Lacoste

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

M. Taipale· 2 shared A. Carpenter· 1 shared A. Madero· 1 shared A.-C. Gingras· 1 shared B. Cimini· 1 shared B. Raught· 1 shared C. Reno· 1 shared D. Hill· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCell Biology

M. Taipale

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2 papers

Recent·Most cited

The co-chaperone DNAJA2 buffers proteasomal degradation of cytosolic proteins with missense mutations

H. A. Baker, J. P. Bernardini, V. Csizmok, A. Madero, S. Kamat, H. Eng, J. Lacoste, F. Yeung, S. Comyn, G. Calabrese, M. Taipale, B. Raught, T. Mayor

The paper identifies cytosolic mutant proteins degraded by the proteasome and shows DNAJA2 stabilizes some mutants while being dispensable for wild-type proteins.

bioRxiv · Feb 15, 2024Cell Biology

Pervasive mislocalization of pathogenic coding variants underlying human disorders

J. Lacoste, M. Haghighi, S. Haider, Z.-Y. Lin, D. Segal, C. Reno, W. W. Qian, X. Xiong, H. Shafqat-Abbasi, P. Ryder, R. Senft, B. Cimini, F. Roth, M. Calderwood, D. Hill, , M. Taipale

The paper develops a high-throughput imaging platform to assess the functional impact of missense variants on protein localization, finding that mislocalization is common in pathogenic variants.

bioRxiv · Sep 5, 2023Cell Biology