A. Carpenter

Pervasive mislocalization of pathogenic coding variants underlying human disorders

The paper develops a high-throughput imaging platform to assess the functional impact of missense variants on protein localization, finding that mislocalization is common in pathogenic variants.

Expressing the pro-apoptotic Reaper protein via insertion into the structural open reading frame of Sindbis virus reduces the ability to infect Aedes aegypti mosquitoes

This study expresses the pro-apoptotic Reaper protein in Sindbis virus to reduce infection in Aedes aegypti mosquitoes, showing reduced midgut and disseminated infection but not viral titer.

Identification of multi-omics molecular signature of acute radiation injury using nonhuman primate model

This study identifies a 4-analyte serum panel to detect radiation exposure in nonhuman primates using multi-omics data from mass spectrometry.

Repurposed High-Throughput Images Enable Biological Activity Prediction For Drug Discovery

The paper repurposes high-throughput imaging data from a glucocorticoid receptor assay to predict activity in unrelated drug discovery assays, significantly increasing hit rates and chemical diversity.