L. Simpson

The Origin And Speciation Of Orchids

This study reconstructs the phylogeny of orchids using genomic data and infers their geographic origin and speciation patterns, finding their origin in Laurasia and recent speciation in Central America.

Single Cell Expression Analysis of Ductal Carcinoma in Situ Identifies Alterations in Epithelial Integrity

This study uses scRNA-seq to analyze DCIS and normal breast tissue, identifying clonal heterogeneity and cell state changes associated with progression to invasive cancer.

Plastid phylogenomics clarifies broad-level relationships in Bulbophyllum (Orchidaceae) and provides insights into range evolution of Australasian section Adelopetalum

This study uses plastid phylogenomics to clarify relationships within Bulbophyllum and sect. Adelopetalum, revealing non-monophyly of several sections and evolutionary patterns in Australasian regions.

Evolutionary relationships and range evolution of greenhood orchids (subtribe Pterostylidinae): insights from plastid phylogenomics

This study uses plastid phylogenomics to infer evolutionary relationships, divergence times, and range evolution in Pterostylidinae orchids, revealing origins in temperate eastern Australia and patterns of dispersal and speciation linked to climatic changes.

SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis

This study shows SARS-CoV-2 infects human engineered heart tissues, causing myocarditis-like features, and identifies ACE2 and proteases as entry factors.

Collagen hydrogel confinement of amyloid-β accelerates aggregation and reduces cytotoxic effects

This study shows that collagen hydrogel confinement of amyloid-β promotes stable β-sheet aggregates and reduces cytotoxicity compared to 2D cultures.

Impact of four common hydrogels on amyloid-β (Aβ) aggregation and cytotoxicity: Implications for 3D models of Alzheimer’s disease

This study examines how four hydrogels affect Aβ aggregation and cytotoxicity in 3D models, finding that all hydrogels reduce Aβ toxicity by altering aggregation dynamics.