Author

J. Lederhofer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Approach:experimental assay· 1 Assay:protein structure· 1

Frequent Co-Authors

M. Kanekiyo· 2 shared Y. Tsybovsky· 2 shared A. Creanga· 1 shared A. J. Borst· 1 shared B. S. Graham· 1 shared C. Seitz· 1 shared C. Yap· 1 shared D. Ellis· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBiophysics

M. Kanekiyo

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2 papers

Recent·Most cited

Breathing and Tilting: Mesoscale simulations illuminate influenza glycoprotein vulnerabilities

L. Casalino, C. Seitz, J. Lederhofer, Y. Tsybovsky, I. A. Wilson, M. Kanekiyo, R. E. Amaro

This study uses mesoscale simulations to analyze the dynamics of influenza glycoproteins, revealing new antigenic states and a vulnerability site in neuraminidase.

bioRxiv · Aug 2, 2022Biophysics

Structure-based design of stabilized recombinant influenza neuraminidase tetramers

D. Ellis, J. Lederhofer, O. J. Acton, Y. Tsybovsky, S. Kephart, C. Yap, R. A. Gillespie, A. Creanga, T. Stephens, D. Pettie, M. Murphy, A. J. Borst, Y.-J. Park, K. K. Lee, B. S. Graham, , M. Kanekiyo

This study designs stabilized recombinant influenza neuraminidase tetramers by uncovering structural principles and improving thermal stability and antibody affinity.

bioRxiv · May 17, 2021Microbiology