D. Ellis

Proteolytic control of the SARS-CoV-2 furin cleavage site defines the phenotypic evolution from the pandemic to endemic state

The paper shows how SARS-CoV-2 variants, particularly Omicron, evolved proteolytic controls at the Spike furin cleavage site to enhance transmission while reducing lower respiratory tract pathogenicity.

Cardiovascular symptoms of PASC are associated with trace-level cytokines that affect the function of human pluripotent stem cell derived cardiomyocytes

This study identifies trace-level cytokines in PASC patients linked to cardiovascular symptoms and shows their impact on cardiomyocyte function using nanotechnology detection.

Antigen spacing on protein nanoparticles influences antibody responses to vaccination

This study shows that antigen spacing on protein nanoparticles affects antibody responses to vaccination, with decreased spacing improving hemagglutination inhibition and neutralization potency.

Combinatorial immune refocusing within the influenza hemagglutinin head elicits cross-neutralizing antibody responses

This study evaluates trihead nanoparticle immunogens to enhance cross-neutralizing antibody responses against influenza H1 viruses by combining immunofocusing techniques.

Virus-like particle displaying SARS-CoV-2 receptor binding domain elicits neutralizing antibodies and is protective in a challenge model

This study develops a virus-like particle vaccine, IVX-411, that elicits neutralizing antibodies and provides protection against multiple SARS-CoV-2 variants in a challenge model.

Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains

This study identifies cryptic transmembrane domains in designed protein nanoparticles that hinder secretion and introduces a computational tool, Degreaser, to remove them while maintaining stability, improving secretion efficiency.

Predation risk differentially affects aphid morphotypes: impacts on prey behavior, fecundity and transgenerational dispersal morphology

This study shows that predation risk affects different aphid morphotypes in distinct ways, altering behavior, fecundity, and transgenerational dispersal morphology.

Structure-based design of stabilized recombinant influenza neuraminidase tetramers

This study designs stabilized recombinant influenza neuraminidase tetramers by uncovering structural principles and improving thermal stability and antibody affinity.

Stabilization of the SARS-CoV-2 Spike receptor-binding domain using deep mutational scanning and structure-based design

This paper designs stabilized SARS-CoV-2 RBD variants using deep mutational scanning and structure-based design, showing improved thermal stability and manufacturability for vaccine applications.

Elicitation of broadly protective immunity to influenza by multivalent hemagglutinin nanoparticle vaccines

Nanoparticle immunogens with four seasonal influenza hemagglutinins elicit neutralizing antibodies against both the head and stem, providing broad protection against diverse influenza strains.