Author

T. Stephens

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 8 Cell Biology· 1 Ecology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 8 Organism:human· 3 Organism:mouse· 3 Assay:proteomics· 3 Organism:virus· 3 Research Focus:cell type annotation· 2 Assay:cryo-EM· 2

Frequent Co-Authors

Y. Tsybovsky· 9 shared P. D. Kwong· 6 shared T. Zhou· 6 shared B. Zhang· 5 shared J. R. Mascola· 5 shared A. Creanga· 4 shared A. S. Olia· 4 shared B. S. Graham· 4 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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9 shared papersImmunology

Y. Tsybovsky

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Vaccine-elicited and naturally elicited antibodies differ in their recognition of the HIV-1 fusion peptide

M. Reveiz, K. Xu, M. Lee, S. Wang, A. S. Olia, D. R. Harris, K. Liu, T. Liu, A. J. Schaub, T. Stephens, Y. Wang, B. Zhang, R. Huang, Y. Tsybovsky, P. D. Kwong, R. Rawi

This study compares vaccine-elicited and naturally elicited antibodies' recognition of HIV-1 fusion peptide sequences, finding that naturally elicited antibodies show greater tolerance to sequence variation.

bioRxiv · Jun 18, 2024Immunology

Climate benefits of seaweed farming: estimating regional carbon emission and sequestration pathways

C. Bullen, J. Driscoll, J. Burt, T. Stephens, M. Hessing-Lewis, E. J. Gregr

This study estimates the carbon emission and sequestration potential of seaweed farming in coastal British Columbia under different industry development scenarios.

bioRxiv · Jun 13, 2023Ecology

Prefusion-Stabilized Lassa Virus Trimer Identifies Neutralizing Nanobodies and Reveals an Apex-Situated Site of Vulnerability

J. Gorman, C. S.-F. Cheung, Z. Duan, Y. Sun, P. Wang, J. C. Boyington, A. Biju, T. Bylund, C. Cheng, L. Ou, T. Stephens, Y. Tsybovsky, R. Verardi, S. Wang, Y. Yang, , P. D. Kwong

This paper develops a prefusion-stabilized Lassa virus GPC, identifies a neutralizing nanobody, and reveals a cleavage-dependent site of vulnerability at the trimer apex.

bioRxiv · Apr 21, 2022 · PreprintImmunology

Vaccine-elicitation of cross-group neutralizing protective antibodies to influenza A viruses

S. M. Moin, J. C. Boyington, S. Boyoglu-Barnum, R. A. Gillespie, G. Cerutti, C. S.-F. Cheung, A. Cagigi, J. R. Gallagher, J. Brand, M. Prabhakaran, Y. Tsybovsky, T. Stephens, B. E. Fisher, A. Creanga, S. Ataca, , M. Kanekiyo

This study shows that co-immunization with stem immunogens from group 1 and 2 influenza A HAs elicits cross-group neutralizing antibodies and protective immunity in multiple animal models.

bioRxiv · Feb 11, 2022 · PreprintImmunology

Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1.1.529

T. Zhou, L. Wang, J. Misasi, A. Pegu, Y. Zhang, D. R. Harris, A. S. Olia, C. A. Talana, E. S. Yang, M. Chen, M. Choe, W. Shi, I.-T. Teng, A. Creanga, C. Jenkins, , P. D. Kwong

The paper identifies potent monoclonal antibodies that neutralize the B.1.1.529 SARS-CoV-2 variant and reveals structural mechanisms enabling their effectiveness.

bioRxiv · Dec 27, 2021Immunology

Structure-based design of stabilized recombinant influenza neuraminidase tetramers

D. Ellis, J. Lederhofer, O. J. Acton, Y. Tsybovsky, S. Kephart, C. Yap, R. A. Gillespie, A. Creanga, T. Stephens, D. Pettie, M. Murphy, A. J. Borst, Y.-J. Park, K. K. Lee, B. S. Graham, , M. Kanekiyo

This study designs stabilized recombinant influenza neuraminidase tetramers by uncovering structural principles and improving thermal stability and antibody affinity.

bioRxiv · May 17, 2021Microbiology

Multimeric nanobodies from camelid engineered mice and llamas potently neutralize SARS-CoV-2 variants

J. Xu, K. Xu, S. K. Jung, A. Conte, J. Lieberman, F. Muecksch, J. C. C. Lorenzi, S. Park, Z. Wang, L. Tessarollo, T. Bylund, G.-Y. Chuang, A. Olia, I.-T. Teng, T. Zhou, , R. Casellas

This paper isolates and characterizes nanobodies from camelids and engineered mice that neutralize SARS-CoV-2 variants through conserved epitopes and multimeric avidity.

bioRxiv · Mar 4, 2021 · PreprintImmunology

Antibodies with potent and broad neutralizing activity against antigenically diverse and highly transmissible SARS-CoV-2 variants

L. Wang, T. Zhou, Y. Zhang, E. S. Yang, C. A. Schramm, W. Shi, A. Pegu, O. K. Oloninyi, A. Ransier, S. Darko, S. R. Narpala, C. Hatcher, D. R. Martinez, Y. Tsybovsky, E. Phung, , Mascol

The paper identifies ultrapotent antibodies from convalescent donors that neutralize SARS-CoV-2 variants and reduce escape mutant generation.

bioRxiv · Feb 25, 2021Immunology

Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains

T. Zhou, Y. Tsybovsky, A. S. Olia, J. Gorman, M. A. Rapp, G. Cerutti, G.-Y. Chuang, P. S. Katsamba, A. Nazzari, J. M. Sampson, A. Schon, P. D. Wang, J. Bimela, W. Shi, I.-T. Teng, , P. D. Kwong

This paper uses cryo-EM to show how SARS-CoV-2 spike protein undergoes pH-dependent structural changes that affect ACE2 binding and antibody evasion.

bioRxiv · Jul 4, 2020 · PreprintImmunology

A comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies

A. Creanga, R. A. Gillespie, B. E. Fisher, S. F. Andrews, L. Hatch, T. Stephens, Y. Tsybovsky, M. C. Crank, A. B. McDermott, J. R. Mascola, B. S. Graham, M. Kanekiyo

The paper develops a fluorescent reporter virus panel to enable high-throughput neutralization profiling of influenza antibodies without requiring high-containment labs.

bioRxiv · Feb 24, 2020Immunology

Megakaryocyte TGFβ1 Partitions Hematopoiesis into Immature Progenitor/Stem Cells and Maturing Precursors

S. Di Giandomenico, P. Rabbany, N. Molle, M. Yabut, G. A. Zeinah, T. Stephens, N. Messali, S. Rafii, J. M. Scandura

This study shows that megakaryocyte-derived TGFβ1 controls hematopoiesis by regulating immature HSPC pools and erythroid precursor survival, improving erythropoiesis efficiency.

bioRxiv · Jul 6, 2019 · PreprintCell Biology