Author

C. Seitz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Approach:comparative / phylogenetic analysis· 1 Assay:cryo-EM· 1

Frequent Co-Authors

J. A. McCammon· 4 shared R. E. Amaro· 3 shared L. Casalino· 2 shared A. Banito· 1 shared A. Deep· 1 shared A. M. Prichard· 1 shared C. Blume· 1 shared C. Schmidt· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersBiophysics

J. A. McCammon

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Targeting Tuberculosis: Novel Scaffolds for Inhibiting Cytochrome bd Oxidase

C. Seitz, S.-H. Ahn, H. Wei, M. Kyte, G. Cook, K. Krausd, J. A. McCammon

This study identifies six new cytochrome bd inhibitor scaffolds through computational screening and validates their activity against Mycobacterium tuberculosis.

bioRxiv · Feb 28, 2024Biochemistry

Somatic gene delivery for flexible in vivo modeling of high-risk sarcoma

R. Imle, D. Blosel, F. Kommoss, E. Zhao, R. Autry, C. Blume, D. Lupar, L. Schmitt, C. Winter, L. Wagner, S. Placke, M. von Eicke, M. Hertwig, H. Peterziel, I. Oehme, , A. Banito

This paper develops a mouse model for high-risk sarcoma by delivering genetic lesions via electroporation, generating multiple sarcoma types and validating their molecular and therapeutic relevance.

bioRxiv · Jan 30, 2024 · PreprintCancer Biology

Glycosylation and Crowded Membrane Effects on Influenza Neuraminidase Stability and Dynamics

C. Seitz, I. Deveci, J. A. McCammon

This study examines how glycosylation and membrane crowding affect the stability and dynamics of influenza neuraminidase through computational simulations of three different systems.

bioRxiv · Sep 10, 2023Biophysics

Breathing and Tilting: Mesoscale simulations illuminate influenza glycoprotein vulnerabilities

L. Casalino, C. Seitz, J. Lederhofer, Y. Tsybovsky, I. A. Wilson, M. Kanekiyo, R. E. Amaro

This study uses mesoscale simulations to analyze the dynamics of influenza glycoproteins, revealing new antigenic states and a vulnerability site in neuraminidase.

bioRxiv · Aug 2, 2022Biophysics

Architecture and self-assembly of the jumbo bacteriophage nuclear shell

T. G. Laughlin, A. Deep, A. M. Prichard, C. Seitz, Y. Gu, E. Enustun, S. Suslov, K. Khanna, E. A. Birkholz, E. Armbruster, J. A. McCammon, R. E. Amaro, J. Pogliano, K. D. Corbett, E. Villa

The paper identifies chimallin as the primary protein forming the bacteriophage nuclear shell and characterizes its self-assembly into closed compartments.

bioRxiv · Feb 14, 2022Biophysics

Multiscale simulations examining glycan shield effects on drug binding to influenza neuraminidase

C. Seitz, L. Casalino, R. Konecny, G. Huber, R. E. Amaro, J. A. McCammon

This study uses multiscale simulations to show glycans reduce drug binding to influenza neuraminidase by sterically blocking the primary binding site.

bioRxiv · Aug 12, 2020Biophysics