Author

V. Krizhanovsky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

L. Roitman· 2 shared A. Agrawal· 1 shared A. C. Greenwald· 1 shared A. Mayo· 1 shared A. Monsonego· 1 shared A. Nemirovsky· 1 shared A. Plotnikov· 1 shared A. Regev· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

L. Roitman

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

CD4 T Cells Acquire Cytotoxic Properties to Modulate Cellular Senescence and Aging

Y. Elyahu, I. Feygin, N. Pinkas, A. Zemer, A. Shicht, O. Berner, E. Eremenko, A. Nemirovsky, K. Reshef, L. Roitman, V. Krizhanovsky, A. Monsonego

This study shows CD4 T cells differentiate into cytotoxic T cells in senescent-rich environments, and reducing senescent cells halts this differentiation, impacting aging and disease.

bioRxiv · Jan 14, 2024Immunology

p16-dependent upregulation of PD-L1 impairs immunosurveillance of senescent cells

J. Majewska, A. Agrawal, A. Mayo, L. Roitman, R. Chatterjee, J. Kralova, T. Landsberger, Y. Katzenelenbogen, T. M. Salame, E. Hagai, N. Stanojevic, I. Amit, U. Alon, V. Krizhanovsky

This study identifies p16-dependent upregulation of PD-L1 in senescent cells as a mechanism to evade immune clearance, showing that anti-PD-L1 treatment can eliminate these cells.

bioRxiv · Jan 30, 2023 · PreprintCell Biology

Pan-cancer single cell RNA-seq uncovers recurring programs of cellular heterogeneity

G. S. Kinker, A. C. Greenwald, R. Tal, Z. Orlova, M. S. Cuoco, J. M. McFarland, A. Warren, C. Rodman, J. A. Roth, S. A. Bender, B. Kumar, J. W. Rocco, P. A. Fernandes, C. C. Mader, H. Keren-Shaul, , I. Tirosh

The paper uses single-cell RNA-seq to analyze cancer cell lines and identifies recurring expression programs of heterogeneity that mirror those in tumors, suggesting intrinsic plasticity contributes to intra-tumoral diversity.

bioRxiv · Oct 21, 2019 · PreprintCancer Biology