J. N. Blaza

This study shows that mitochondrial DNA mutations in complex I genes drive aerobic glycolysis, enhancing immune checkpoint blockade response in tumors.

This paper reports the cryo-EM structure and kinetics of sulfolactaldehyde dehydrogenase from Rhizobium leguminosarum, revealing its cofactor usage and catalytic mechanism in sulfolactate synthesis.

This study identifies how biguanides inhibit respiratory complex I by binding in the quinone channel and causing a chaotropic effect.

This study determines the structure of the deactive state of Bos taurus complex I using cryo-EM, revealing structural changes associated with the transition from active to deactive states.