Author

J. P. Gudikote

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Cancer Biology· 1

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

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A. Poteete· 1 shared E. P. Sulman· 1 shared F. M. Johnson· 1 shared F. Zhang· 1 shared J. Heymach· 1 shared J. Wang· 1 shared J.-C. Bourdon· 1 shared L. Li· 1 shared

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1 shared paperCancer Biology

A. Poteete

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1 paper

Recent·Most cited

Cancer BiologybioRxivPreprintApr 6, 2020

Inhibition of nonsense-mediated decay rescues functional p53β/γ isoforms in MDM2-amplified cancers

J. P. Gudikote, T. Cascone, A. Poteete…·J. Heymach

The paper shows that inhibiting nonsense-mediated decay increases expression of p53β/γ isoforms, which are resistant to MDM2 degradation, thereby restoring p53 function in cancers with MDM2 amplification, HPV infection, or specific p53 mutations.

DOI 10.1101/2020.04.06.026955

humanproteomics

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