Author

J. Heymach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1

Frequent Co-Authors

J. Wang· 2 shared L. Shen· 2 shared L. Yang· 2 shared A. A. Osman· 1 shared A. Dhawan· 1 shared A. Duarte· 1 shared A. G. Serrano· 1 shared A. Gazdar· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

J. Wang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

YAP1 status defines two intrinsic subtypes of LCNEC with distinct molecular features and therapeutic vulnerabilities

C. A. Stewart, L. Diao, Y. Xi, R. Wang, K. Ramkumar, A. G. Serrano, B. L. Rodriguez, B. B. Morris, L. Shen, B. Zhang, Y. Yang, S. H. Hamad, R. J. Cardnell, A. Duarte, M. Sahu, , C. M. Gay

bioRxiv · Dec 19, 2023Cancer Biology

FAK drives resistance to therapy in HPV-negative head and neck cancer in a p53-dependent manner.

P. M. Pifer, L. Yang, M. Kumar, T. Xie, M. Frederick, A. Hefner, B. Beadle, D. Molkentine, J. Molkentine, A. Dhawan, M. Abdelhakiem, A. A. Osman, J. N. Myers, C. R. Pickering, V. C. Sandulache, , H. D. Skinner

This study identifies FAK as a driver of therapy resistance in HPV-negative HNSCC, showing its role is dependent on mutant TP53.

bioRxiv · Jun 3, 2022Cancer Biology

Inhibition of nonsense-mediated decay rescues functional p53β/γ isoforms in MDM2-amplified cancers

J. P. Gudikote, T. Cascone, A. Poteete, P. Sitthideatphaiboon, Q. Wu, N. Morikawa, F. Zhang, S. Peng, P. Tong, L. Li, L. Shen, M. Nilsson, P. Jones, E. P. Sulman, J. Wang, , J. Heymach

The paper shows that inhibiting nonsense-mediated decay increases expression of p53β/γ isoforms, which are resistant to MDM2 degradation, thereby restoring p53 function in cancers with MDM2 amplification, HPV infection, or specific p53 mutations.

bioRxiv · Apr 6, 2020 · PreprintCancer Biology

Lung Cancer Explorer (LCE): an open web portal to explore gene expression and clinical associations in lung cancer

L. Cai, S. Lin, Y. Zhou, L. Yang, B. Ci, Q. Zhou, D. Luo, B. Yao, H. Tang, J. Allen, K. Huffman, A. Gazdar, J. Heymach, I. Wistuba, G. Xiao, , Y. Xie

The paper constructs a lung cancer database with gene expression and clinical data from 6,700 patients and develops an open web portal for data exploration and analysis.

bioRxiv · Feb 24, 2018Cancer Biology