Author

J. Prochazka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

R. Sedlacek· 5 shared A. Drobek· 2 shared A. A. Shanbhag· 1 shared A. Celoria· 1 shared A. Cherian· 1 shared A. Ciabattini· 1 shared A. Franzetti-Pellanda· 1 shared A. Neuwirth· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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5 shared papersImmunology

R. Sedlacek

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

ABIN1 is a negative regulator of effector functions in cytotoxic T cells

S. Janusova, D. Paprckova, J. Michalik, V. Uleri, A. Drobek, E. Salyova, L. Chorfi, A. Neuwirth, J. Prochazka, R. Sedlacek, P. Draber, O. Stepanek

This study identifies ABIN1 as a negative regulator of effector functions in cytotoxic T cells, showing its role in suppressing NF-κB and p38 pathways.

bioRxiv · Oct 25, 2023Immunology

Aberrant activation of the innate immune sensor PKR by self dsRNA is prevented by direct interaction with ADAR1

K. Sinigaglia, A. Cherian, D. Vukic, J. Melicherova, P. Linhartova, Q. Du, L. Zerad, S. Stejskal, R. Malik, J. Prochazka, N. Bondurand, R. Sedlacek, M. A. O'Connell, L. P. Keegan

The paper identifies PKR as a second dsRNA sensor aberrantly activated in Adar mutant mice and shows ADAR1 directly inhibits PKR through dsRNA-binding.

bioRxiv · Aug 29, 2023 · PreprintImmunology

Human neutralizing antibodies to cold linear epitopes and to subdomain 1 of SARS-CoV-2

F. Bianchini, V. Crivelli, M. E. Abernathy, C. Guerra, M. Palus, J. Muri, H. Marcotte, A. Piralla, M. Pedotti, R. De, L. Simonelli, M. Matkovic, C. Toscano, M. Biggiogero, V. Calvaruso, , Ru

The paper identifies broadly cross-reactive neutralizing antibodies against SARS-CoV-2 variants using coldspot-guided antibody discovery.

bioRxiv · Nov 24, 2022 · PreprintImmunology

DDI2 protease activity controls embryonic development and inflammation via TCF11/NRF1

M. Siva, S. Haberecht-Müller, M. Prochazkova, J. Prochazka, F. Sedlak, K. Chawengsaksophak, P. Kasparek, R. Sedlacek, J. Konvalinka, E. Krüger, K. Grantz Saskova

This study shows that DDI2 protease is essential for embryonic development and immune balance by regulating TCF11/NRF1 and proteostasis.

bioRxiv · Dec 16, 2020Cell Biology

Regulation of neutrophil NADPH oxidase by PSTPIP2 affects bone damage in murine autoinflammatory osteomyelitis

J. Kralova, A. Drobek, J. Prochazka, F. Spoutil, D. Glatzova, S. Borna, J. Pokorna, T. Skopcova, P. Angelisova, M. Gregor, P. Kovarik, R. Sedlacek, T. Brdicka

This study shows that PSTPIP2 regulates neutrophil NADPH oxidase, and its loss leads to increased ROS production and bone damage in a murine model of autoinflammatory osteomyelitis.

bioRxiv · Aug 6, 2019 · PreprintImmunology