R. Malik

Selective inflammation of the tumor microenvironment and invigorated T cell-mediated tumor control upon induced systemic inactivation of TREX1

This study shows that systemic TREX1 inhibition enhances anti-tumor immunity by increasing T cell infiltration and activity in tumors while sparing other tissues.

Nucleic Acid Mediated Activation of a Short Prokaryotic Argonaute Immune System

This study resolves crystal and cryo-EM structures of the SPARTA system to elucidate its activation mechanism involving nucleic acid binding and oligomerization.

Aberrant activation of the innate immune sensor PKR by self dsRNA is prevented by direct interaction with ADAR1

The paper identifies PKR as a second dsRNA sensor aberrantly activated in Adar mutant mice and shows ADAR1 directly inhibits PKR through dsRNA-binding.

Angie-LAMP for diagnosis of human eosinophilic meningitis using dog as proxy: A LAMP assay for Angiostrongylus cantonensis DNA in cerebrospinal fluid

This paper develops a LAMP assay (Angie-LAMP) for detecting Angiostrongylus cantonensis DNA in canine cerebrospinal fluid, showing comparable sensitivity to qPCR and improved portability for field use.

Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblastdriven nutritional support and immunosuppression

This study identifies Netrin G1 as a promoter of pancreatic ductal adenocarcinoma tumorigenesis by enhancing cancer-associated fibroblast-driven metabolic support and immunosuppression.