P. Solomon

Impact of ectopic calcification on vascular oxygenation in placental dysfunction models: Simultaneous in vivo assessment with multi-parametric ultrasound and photoacoustic imaging

mRNA display reveals a class of high-affinity bromodomain-binding motifs that are not found in the human proteome

The paper uses mRNA display to identify high-affinity bromodomain-binding motifs not present in the human proteome, revealing novel binding modes and suggesting evolutionary pressure against strong binders.

Simple and efficient heterologous expression of necrosis-inducing effectors using the model plant Nicotiana benthamiana

This paper describes a method to express fungal effector proteins in Nicotiana benthamiana, enabling efficient necrosis induction in host plants.

Remarkable recent changes in genetic diversity of the avirulence gene AvrStb6 in global populations of the wheat pathogen Zymoseptoria tritici

The paper analyzes changes in AvrStb6 genetic diversity in Zymoseptoria tritici isolates from 2013-2017, finding a loss of the original avirulence isoform and dominance of a single virulence isoform.

Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike

This paper identifies and engineers multivalent human VH domains that neutralize SARS-CoV-2 by targeting distinct epitopes on the Spike protein's ACE2 binding interface, showing increased affinity and potency.

Engineered ACE2 receptor traps potently neutralize SARS-CoV-2

This paper describes engineered ACE2 receptor traps that potently neutralize SARS-CoV-2 by blocking viral entry through enhanced binding affinity.

The crystal structure of SnTox3 from the necrotrophic fungus Parastagonospora nodorum reveals a unique effector fold and insights into Kex2 protease processing of fungal effectors

The paper determines the crystal structure of SnTox3, a fungal effector, revealing a novel β-barrel fold and showing that it is a pre-pro-protein processed by Kex2 protease.

Trimeric SARS-CoV-2 Spike interacts with dimeric ACE2 with limited intra-Spike avidity

This study investigates the interaction between SARS-CoV-2 Spike and ACE2, showing that dimeric ACE2 binds with high affinity to Spike and blocks viral entry, with limited intra-Spike avidity.

Cyclic peptides can engage a single binding pocket through multiple, entirely divergent modes

The paper identifies high-affinity, specific cyclic peptide inhibitors of BET bromodomains using RaPID screening, revealing diverse binding modes and structures.