Author

J. R. Kirsch

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Biology Disciplines

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Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:multiome· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

D. Kenney· 1 shared E. Chavez· 1 shared F. Douam· 1 shared J. E. McGee· 1 shared M. W. Grinstaff· 1 shared T.-Y. Shih· 1 shared W. W. Wong· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperBioengineering

D. Kenney

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1 paper

Recent·Most cited

BioengineeringbioRxivSep 15, 2023

Complete substitution with modified nucleotides suppresses the early interferon response and increases the potency of self-amplifying RNA

J. E. McGee, J. R. Kirsch, D. Kenney…·M. W. Grinstaff

This paper shows that complete substitution of nucleotides in self-amplifying RNA (saRNA) reduces interferon response and enhances expression, improving vaccine potency.

DOI 10.1038/s41587-024-02306-z

humanmouse

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