Author

J. Reddy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:mouse· 2 Approach:statistical model· 2

Frequent Co-Authors

K. Lawrenson· 4 shared M. L. Freedman· 3 shared R. Drapkin· 3 shared R. I. Corona· 3 shared R. Nameki· 3 shared X. Lin· 3 shared A. Gusev· 2 shared B. Y. Karlan· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

K. Lawrenson

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Author profile →

6 papers

Recent·Most cited

Rewiring of master transcription factor cistromes during high-grade serous ovarian cancer development

R. Nameki, H. Chang, P. H. Yu, F. Abbasi, X. Lin, J. Reddy, M. Haro, M. Fonseca, M. L. Freedman, R. Drapkin, R. Corona, K. Lawrenson

This study identifies MECOM, PAX8, SOX17, and WT1 as master regulators in HGSC, showing their rewired cistromes and tumor-specific inhibition potential.

bioRxiv · Apr 11, 2023 · PreprintCancer Biology

Dissecting the Cellular Landscape and Transcriptome Network in Viral Myocarditis by Single-Cell RNA Sequencing

N. Lasrado, N. Borcherding, R. Arumugam, T. K. Starr, J. Reddy

This study uses single-cell RNA sequencing to analyze heart cells from healthy and myocarditic mice, identifying changes in immune and non-immune cell populations and their transcriptomic roles in viral myocarditis.

bioRxiv · May 16, 2021Immunology

PAX8 orchestrates an angiogenic program through interaction with SOX17

D. Chaves-Moreira, M. A. Mitchell, C. Arruza, P. Rawat, S. Sidoli, R. Nameki, J. Reddy, R. I. Corona, S. Ma, B. Winterhoff, G. E. Konecny, B. A. Garcia, D. C. Brady, K. Lawrenson, P. J. Morin, R. Drapkin

This study identifies SOX17 as a PAX8-interacting partner and shows their role in regulating tumor angiogenesis in ovarian cancer, suggesting a new therapeutic target.

bioRxiv · Sep 9, 2020 · PreprintCancer Biology

Evidence for anti-viral effects of complete Freunds adjuvant in the mouse model of enterovirus infection

A. Gangaplara, C. Massilamany, N. Lasrado, D. Steffen, J. Reddy

The paper shows that complete Freund's adjuvant (CFA) alone can protect mice from CVB3-induced myocarditis and pancreatitis, suggesting its potential as an adjuvant for viral vaccines.

bioRxiv · May 27, 2020Immunology

Predicting master transcription factors from pan-cancer expression data

J. Reddy, M. A. S. Fonseca, R. I. Corona, R. Nameki, F. Segato Dezem, I. A. Klein, H. Chang, D. Chaves-Moreira, L. Afeyan, T. M. Malta, X. Lin, F. Abbasi, A. Font-Tello, T. Sabedot, P. Cejas, , K. Lawrenson

This paper introduces CaCTS, an algorithm that identifies candidate master transcription factors (MTFs) across 34 cancer types using RNA-seq data, revealing novel MTFs and functional groupings.

bioRxiv · Nov 12, 2019Cancer Biology

Non-coding Somatic Mutations Converge on the PAX8 Pathway in Epithelial Ovarian Cancer

R. I. Corona, J.-H. Seo, X. Lin, D. J. Hazelett, J. Reddy, F. Abassi, Y. G. Lin, P. Y. Mhawech-Fauceglia, J. Lester, S. P. Shah, D. G. Huntsman, A. Gusev, B. Y. Karlan, B. P. Berman, M. L. Freedman, , K. Lawrenson

The paper identifies histotype-specific regulatory elements in ovarian cancer by integrating chromatin landscapes and somatic mutations, highlighting the PAX8 pathway's role in tumor development.

bioRxiv · Feb 1, 2019Cancer Biology