S. Ma

CDK4/6 inhibitors promote PARP1 degradation and act synergistically with PARP inhibitors in non-small cell lung cancer

This study shows CDK4/6 inhibitors promote PARP1 degradation and synergize with PARP inhibitors to kill NSCLC cells by enhancing DNA damage and apoptosis.

Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumors

The paper identifies NRF2-driven myeloid progenitor dysregulation that sustains immunosuppressive macrophages in tumors, showing NRF2 inhibition reduces their survival and enhances antitumor immunity.

PSMA-Guided PROTAC Degraders for Tumor-Specific Protein Degradation in Prostate Cancer

This study develops PSMA-guided PROTACs for prostate cancer, showing they selectively degrade target proteins in PSMA-overexpressing cells and improve therapeutic effects in vivo.

CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

This study identifies convergent therapeutic targets for chemoresistance in cancer using CRISPR screens across multiple drug conditions and cancer models.

CTHRC1+ Fibroblasts and SPP1+ Macrophages Synergistically Contribute to Pro-Tumorigenic Tumor Microenvironment in Pancreatic Ductal Adenocarcinoma

This study identifies SPP1+ macrophages and CTHRC1+ fibroblasts as synergistic contributors to an immunosuppressive tumor microenvironment in PDAC, linked to poor prognosis.

Use of steric blocking antisense oligonucleotides for the targeted inhibition of junction containing precursor microRNAs

This study demonstrates that steric blocking antisense oligonucleotides can inhibit pre-miRNA processing by targeting structural junctions, validating their use in modulating miRNA production.

QM/MM simulations of EFGR with afatinib reveal the role of the beta-dimethylaminomethyl substitution

The paper uses QM/MM simulations to study the reaction mechanism of afatinib with Cys797 in EGFR, revealing a Michael addition mechanism involving deprotonation and stabilization by Asp800.

Jianpi Jiedu Recipe inhibits proliferation through reactive oxygen species-induced incomplete autophagy and reduces PD-L1 expression in colon cancer

Unleashing precision and freedom of optical manipulation: Software-aided real-time precision opto-control of intracellular molecular activities and cell functions

This paper introduces a software-assisted real-time optical manipulation platform for precise control of intracellular processes and cell functions.

Quantification of cellular phototoxicity of organelle stains by the dynamics of microtubule polymerization

The paper quantifies early-stage phototoxicity of organelle stains by analyzing microtubule polymerization dynamics in live cells under different conditions.

Discrimination of Isomeric Glycans via High-sensitive Engineered Nanopore

This paper designs an engineered nanopore to distinguish isomeric glycans with high sensitivity and achieves over 90% separation accuracy without machine learning.

Mass spectrometry imaging links interxylary cork formation with phytochemical distribution in Scutellaria baicalensis

This study uses mass spectrometry imaging to show that interxylary cork formation in Scutellaria baicalensis correlates with spatial phytochemical distribution, revealing distinct flavonoid accumulation patterns in different root tissue decay stages.

Asymmetrical Bi-antennary Glycans Prepared by a Stop-and-Go Strategy Reveal Receptor Binding Evolution of Human Influenza A Viruses

This paper develops a stop-and-go chemoenzymatic method to synthesize asymmetrical bi-antennary glycans and uses them to study receptor binding evolution of human influenza A viruses.

In vivo screening for toxicity-modulating drug interactions identifies antagonism that protects against ototoxicity in zebrafish

The paper identifies drug interactions that protect against ototoxicity in zebrafish using a novel high-throughput screening method.

Stomatal maturomics: identifying genes regulating guard cell maturation and function formation from single-cell transcriptomes

The paper identifies 586 genes up-regulated during stomata maturation using single-cell RNA-seq data and shows two TFs regulate guard cell size and function.

Proteomic Stratification of Prognosis and Treatment Options for Small Cell Lung Cancer

This study uses proteomic profiling to stratify small cell lung cancer into three subtypes with distinct clinical outcomes and treatment responses, identifying potential therapeutic targets and improving prognosis prediction.

KatG catalase deficiency confers bedaquiline hyper-susceptibility to isoniazid resistant Mycobacterium tuberculosis

This study identifies KatG catalase deficiency in INH-resistant M. tuberculosis as a factor contributing to hyper-susceptibility to bedaquiline.

Data-driven optimization yielded a highly-efficient CRISPR/Cas9 system for gene editing in Arabidopsis

The paper develops a CRISPR/Cas9 system for Arabidopsis using the NUC1 promoter, achieving high editing efficiency and stable inheritance in the T2 generation.

NeuroMotion: Open-source Simulator with Neuromechanical and Deep Network Models to Generate Surface EMG signals during Voluntary Movement

NeuroMotion generates synthetic EMG signals during voluntary movements by integrating musculoskeletal models, neural networks, and motor unit models, enabling analysis of neuromechanical interactions.

The ubiquitin ligase STUB1 suppresses tumorigenesis of renal cell carcinomas through regulating YTHDF1 stability

This study identifies STUB1 as a tumor suppressor in ccRCC by promoting YTHDF1 degradation, with low STUB1 expression linked to poor patient outcomes.

Replication stress inducing ELF3 upregulation promotes BRCA1-deficient breast tumorigenesis in luminal progenitors

The paper identifies replication stress as a driver of BRCA1-deficient breast tumorigenesis in luminal progenitors, showing ELF3 upregulation promotes this process.

Spatiotemporal precise optical manipulation of intracellular molecular activities

This paper develops a closed-loop optoelectronic system to precisely control molecular activities in live cells, demonstrating spatiotemporal manipulation of reactive oxygen species and tubulin polymerization.

Oligomeric state of β-coronavirus non-structural protein 10 stimulators studied by OmniSEC and Small Angle X-ray Scattering

This study characterizes the oligomeric state and structure of nsp10 from SARS, MERS, and SARS-CoV-2 using biochemical and biophysical methods, revealing it is predominantly monomeric and globular.

High-confidence placement of difficult-to-fit fragments into electron density by using anomalous signals - a case study using hits targeting SARS-CoV-2 non-structural protein 1

This paper demonstrates a method to identify multiple binding orientations of small molecule fragments using anomalous signals from sulphur and chlorine atoms, applied to SARS-CoV-2 nsp1 fragments.

A KDELR-mediated ER retrieval system guides the signaling pathways of UPR and AMPK to maintain cellular homeostasis

This study shows that the KDELR/Erd2-mediated ER retrieval system regulates UPR and AMPK signaling to maintain cellular homeostasis by affecting mitochondrial respiration and ROS levels.

AGILE Platform: A Deep Learning-Powered Approach to Accelerate LNP Development for mRNA Delivery

AGILE uses deep learning and combinatorial chemistry to rapidly design and evaluate ionizable lipids for mRNA delivery, revealing cell-specific preferences for lipid structures.

Ketone-loading as A Novel Sports Nutrition Strategy: Chronic Ketone Supplementation Elicits Further Favorable Metabolic Changes in Keto-adapted Mice

This study shows that chronic exogenous ketone body administration in keto-adapted mice increases circulating ketone bodies and enhances gene expression related to fatty acid oxidation and energy homeostasis.

Probing Altered Receptor Specificities of Antigenically Drifting Human H3N2 Viruses by Chemoenzymatic Synthesis, NMR and Modeling

The paper examines altered receptor specificities of H3N2 influenza viruses using NMR and computational methods to identify binding interactions with extended N-glycans.

Neutrophil-specific STAT4 deficiency reduces atherogenesis and improves plaque stability via reduced neutrophil activation and recruitment to aortas.

This study shows that reducing STAT4 in neutrophils lowers atherosclerosis and improves plaque stability by decreasing neutrophil activation and their migration to aortas.

An ULK1/2-PXN mechanotransduction complex suppresses breast cancer cell migration

This study identifies ULK1/2 as regulators of PXN-dependent mechanotransduction in breast cancer cells, showing their role in inhibiting migration by modulating focal adhesion assembly.