P. Cejas

HOXB13 alters chromatin accessibility in prostate cancer through interactions with the SWI/SNF complex

This study shows HOXB13 promotes prostate cancer proliferation by altering chromatin accessibility through interactions with the SWI/SNF complex, particularly in AR-negative castration-resistant prostate cancer.

BCOR and BCORL1 mutations disrupt PRC1.1 repressive function in leukemia by unlinking the RING-PCGF1 enzymatic core from target genes

This study shows BCOR and BCORL1 mutations disrupt PRC1.1 function in leukemia by separating its enzymatic core from chromatin targets, leading to treatment resistance.

FGFR inhibitor mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance

The paper shows that FGFR inhibitors cause SWI/SNF complex dismissal from YAP-dependent enhancers, leading to adaptive resistance in TNBC through epigenetic and metabolic changes.

In Vivo CRISPR Screens Identify E3 Ligase Cop1 as a Modulator of Macrophage Infiltration and Cancer Immunotherapy Target

The paper identifies Cop1 as a modulator of macrophage infiltration and cancer immunotherapy in TNBC by using in vivo CRISPR screens and multi-omics analyses.

Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

The paper identifies FOXA1 reprogramming in NEPC and shows its role in maintaining NE lineage features through epigenomic profiling.

Subtype Heterogeneity and Epigenetic Convergence in Neuroendocrine Prostate Cancer

This study identifies two distinct subtypes of neuroendocrine prostate cancer based on neuronal transcription factors and highlights their epigenetic convergence and therapeutic implications.

Predicting master transcription factors from pan-cancer expression data

This paper introduces CaCTS, an algorithm that identifies candidate master transcription factors (MTFs) across 34 cancer types using RNA-seq data, revealing novel MTFs and functional groupings.