J. Reimand

The paper identifies survival-associated ion permeome genes across 29 cancer types and shows their role in glioblastoma aggression through functional experiments.

The paper analyzes the impact of mutational signatures from tobacco smoking and APOBEC activity on protein-truncating mutations in 12,341 cancer genomes across 18 types, showing their enrichment in key cancer pathways and tumor suppressors.

The paper identifies cancer driver cistromes in luminal breast cancer by analyzing non-coding mutations in cis-regulatory elements from ATAC-seq data and integrating them with somatic mutations.

The paper identifies 179 prognostic lncRNAs across 29 cancer types using machine learning, showing their association with patient risk and tumor subtypes.

The paper identifies 41 frequently mutated regulatory elements in cancer genomes, enriched in non-coding mutations and linked to gene expression control through chromatin interactions.