Species-specific LUBAC-mediated M1 ubiquitination regulates necroptosis by segregating the cellular distribution and fate of activated MLKL
N. Weinelt, K. N. Waechtershaeuser, S. Smith, G. Andrieux, T. Das, B. Jeiler, J. Roedig, L. Feist, B. Rotter, M. Boerries, F. Pampaloni, S. J. L. van Wijk
The paper identifies LUBAC-mediated M1 ubiquitination as a species-specific checkpoint regulating necroptosis by controlling MLKL membrane accumulation in human cells and organoids.
bioRxiv · Dec 8, 2022 · PreprintCell Biology