R. Schubert

The ataxia-telangiectasia disease protein ATM controls vesicular protein secretion via CHGA and microtubule dynamics via CRMP5

This study identifies ATM's role in regulating vesicular protein secretion through CHGA and microtubule dynamics via CRMP5 in neurons, linking A-T neural atrophy to growth cone collapse.

Crystal structure of a bacterial photoactivated adenylate cyclase determined at room temperature by serial femtosecond crystallography

The paper determines the crystal structure of a bacterial photoactivated adenylate cyclase at room temperature using serial femtosecond crystallography and compares it with cryo structures to study structural changes upon light exposure.

Abatacept treatment in LRBA deficient patients results in an increase in circulating FoxP3+ Helios + natural Treg

This study examines Treg subpopulations in LRBA-deficient patients before, during, and after abatacept treatment, finding increased natural Treg levels and decreased sIL2R levels.

Light-induced Trpin/Metout switching during BLUF domain activation in ATP-bound photoactivatable adenylate cyclase OaPAC

This study investigates the light-induced structural changes in OaPAC's BLUF domain, revealing a Trpin/Metout transition and conformational shifts during ATP activation.

SARS-CoV-2 papain-like protease PLpro in complex with natural compounds reveal allosteric sites for antiviral drug design

This study identifies three natural compounds that inhibit SARS-CoV-2 PLpro by binding to the ISG15/Ub-S2 allosteric site, showing antiviral activity and potential for drug design.

USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING

This study identifies USP22 as a regulator of STING and type III IFN signaling, showing its role in SARS-CoV-2 infection and antiviral defense in human intestinal epithelial cells.

Structure of the Lysinibacillus sphaericus Tpp49Aa1 pesticidal protein elucidated from natural crystals using MHz-SFX

This paper determines the structure of Tpp49Aa1 using MHz-SFX and investigates its interaction with Cry48Aa1, expanding its known target range to include additional mosquito species.

Hallmarks of Alpha- and Betacoronavirus non-structural protein 7+8 complexes

This study determines the stoichiometry and topology of nsp7+8 complexes from seven coronaviruses using mass spectrometry and biophysical techniques, revealing three clustering groups with distinct assembly patterns.

Preparation and characterization of phospholipid stabilized nanoemulsions in small-scale

This paper develops a small-scale method to prepare phospholipid-stabilized nanoemulsions with minimal liposome formation, achieving stable nanoemulsions with particle size <200 nm and PDI <0.1.