Cell BiologybioRxivPreprint
Species-specific LUBAC-mediated M1 ubiquitination regulates necroptosis by segregating the cellular distribution and fate of activated MLKL
N. Weinelt, K. N. Waechtershaeuser, S. Smith…·S. J. L. van Wijk
The paper identifies LUBAC-mediated M1 ubiquitination as a species-specific checkpoint regulating necroptosis by controlling MLKL membrane accumulation in human cells and organoids.
DOI 10.1101/2022.12.08.519265