M. Wan

Senescence of endplate osteoclasts induces sensory innervation and spinal pain

This study identifies senescent osteoclasts in spinal models as contributors to pain through nerve growth and vessel formation, showing their removal reduces hypersensitivity.

Wnt-associated adult stem cell marker Lgr6 is required for osteogenesis and fracture healing

This study shows that Lgr6 is essential for osteogenesis and fracture healing by maintaining bone volume and promoting stem cell activity in mice.

Senescent Preosteoclast Secretome Promotes Metabolic Syndrome Associated Osteoarthritis through Cyclooxygenase 2

This study identifies a senescent preosteoclast secretome-COX2/PGE2 axis as a driver of metabolic syndrome-associated osteoarthritis, with selective COX2 inhibitors showing therapeutic potential.

Peritoneal M2 macrophage-derived extracellular vesicles as natural multi-target nanotherapeutics to attenuate cytokine storm after severe infections

This study shows that M2 macrophage-derived extracellular vesicles reduce cytokine storm by targeting multiple pathways and can act as nanodecoys against SARS-CoV-2.

Miniature inverted-repeat transposable elements drive rapid microRNA diversification in angiosperms

The paper identifies MITEs as a source of new miRNAs in angiosperms, showing they rapidly diversify miRNA repertoires through transposition and transcription.

Integrative molecular and clinical profiling of acral melanoma identifies LZTR1 as a key tumor promoter and therapeutic target

Quantitative 3D Imaging of the Cranial Microvascular Environment at Single-Cell Resolution

The paper introduces a 3D imaging platform to study vascular-skeletal interactions in murine cranial bones, revealing spatial correlations between blood vessels and progenitors, and highlighting osteoclast roles in vascular maintenance.

Single-cell analyses identify tobacco smoke exposure-associated, dysfunctional CD16+ CD8 T cells with high cytolytic potential in peripheral blood

This study identifies smoking-associated, dysfunctional CD16+ CD8 T cells with high cytolytic potential in peripheral blood using single-cell RNA sequencing.

Deubiquitination of phosphoribosyl-ubiquitin conjugates by PDE domain-containing Legionella effectors

This paper identifies DupA and DupB as deubiquitinases that reverse PR-ubiquitination, a novel modification mediated by Legionella effectors, and shows their role in modulating host-pathogen interactions.

Protein polyglutamylation catalyzed by the bacterial Calmodulin-dependent pseudokinase SidJ

This study identifies SidJ as a bacterial pseudokinase that catalyzes polyglutamylation of SdeA, a Legionella effector, in a CaM-dependent manner, suppressing ADP-ribosylation.