Author

J. Sprooten

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:deep learning· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

A. D. Garg· 2 shared I. Vanmeerbeek· 2 shared J. Borst· 2 shared S. De Vleeschouwer· 2 shared S. Naulaerts· 2 shared S. Tejpar· 2 shared A. A. Martinez· 1 shared A. Calvet· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersImmunology

A. D. Garg

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Author profile →

2 papers

Recent·Most cited

A lymph node-to-tumour PD-L1+macrophage circuit antagonizes dendritic cell immunotherapy

J. Sprooten, I. Vanmeerbeek, A. Datsi, J. Govaerts, D. Borras, S. Naulaerts, R. Laureano, A. Calvet, M. Kuballa, M. Sabel, M. Rapp, C. Knobbe-Thomsen, P. Liu, L. Zhao, O. Kepp, , A. D. Garg

This paper shows that DC vaccines can activate PD-L1+ macrophages in lymph nodes and tumors, creating an immunosuppressive circuit that limits their effectiveness, but this can be overcome by combining with PD-L1 blockade.

Cell Reports Medicine · Jan 1, 2024Peer-reviewedImmunology

Immunogenomic, single-cell and spatial dissection of CD8+T cell exhaustion reveals critical determinants of cancer immunotherapy

S. Naulaerts, D. M. Borras, A. A. Martinez, J. Messiaen, Y. Van Herck, L. Gelens, T. Venken, I. Vanmeerbeek, S. More, J. Sprooten, O. Bechter, G. Bergers, A. Liston, S. De Vleeschouwer, B. J. Van den Eynde, , A. D. Garg

This study identifies distinct CD8+T cell states in cancer patients using multi-omics data, showing that dysfunctional states resist immunotherapy while exhausted states can be targeted with specific treatments.

bioRxiv · Nov 22, 2021Immunology