J. Borst

A lymph node-to-tumour PD-L1+macrophage circuit antagonizes dendritic cell immunotherapy

This paper shows that DC vaccines can activate PD-L1+ macrophages in lymph nodes and tumors, creating an immunosuppressive circuit that limits their effectiveness, but this can be overcome by combining with PD-L1 blockade.

TNFR2 costimulation differentially impacts regulatory and conventional CD4+ T-cell metabolism

This study examines how TNFR2 costimulation affects the metabolism of regulatory and conventional CD4+ T-cells, revealing distinct metabolic impacts on each cell type.

Immunogenomic, single-cell and spatial dissection of CD8+T cell exhaustion reveals critical determinants of cancer immunotherapy

This study identifies distinct CD8+T cell states in cancer patients using multi-omics data, showing that dysfunctional states resist immunotherapy while exhausted states can be targeted with specific treatments.

Proteomics reveals unique identities of human TGF-β-induced and thymus-derived CD4+ regulatory T cells

The paper uses proteomics to compare TGF-β-induced iTreg cells with thymus-derived tTreg and Tconv cells, finding iTreg cells have distinct protein expression patterns and lack key Treg signatures.

Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells

This study shows that ATX secreted by melanoma cells repels CD8+ T cells, reducing their infiltration into tumors and impairing anti-tumor immunity.

The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8+ T cells

This study shows that DOT1L prevents premature differentiation of CD8+ T cells and maintains their epigenetic identity, independent of antigen exposure.

Radiotherapy and cisplatin increase immunotherapy efficacy by enabling local and systemic intratumoral T-cell activity

This study shows radiotherapy and cisplatin enhance immunotherapy efficacy in breast cancer by overcoming PD-1-independent T-cell suppression in the tumor microenvironment.