Mechanism by which Aurora B inhibitors promotes RB and p53-dependent senescence.
S. Vora, A. Andrew, R. P. Kumar, D. Nazareth, M. Fernando, M. J. Jones, Y. He, J. Hooper, N. A. McMillan, J. Urosevic, J. Saeh, J. Travers, B. Gabrielli
This study investigates how Aurora B inhibitors induce polyploidy and shows that higher ploidy states reduce long-term proliferative potential in cells with functional RB and p53.
bioRxiv · Mar 27, 2024 · PreprintCell Biology