J. Ward

Unlocking cellular plasticity: Enhancing human iPSC reprogramming through bromodomain inhibition and extracellular matrix gene expression regulation

This study shows that PFI-3 enhances iPSC reprogramming by promoting mesenchymal-epithelial transition and reducing extracellular matrix gene expression in human fibroblasts.

Breakthrough: A First-In-Class Virtual Simulator for Dose Optimization of ACE Inhibitors in Veterinary Cardiology

This study develops a virtual simulator for optimizing benazepril dosing in dogs with CHF using QSP modeling and provides a web-app for veterinary use.

Positive strand RNA viruses differ in the constraints they place on the folding of their negative strand

The paper investigates differences in conformational constraints on negative strand RNA folding among positive strand RNA viruses, finding significant variation in ribozyme activity and duplex formation.

A prebiotic basis for ATP as the universal energy currency

This paper investigates the prebiotic chemistry of ATP, showing that acetyl phosphate could have driven protometabolism before ATP synthesis and that Fe3+ ions favor ADP phosphorylation to ATP.

Development of a Novel Index to Characterise Arterial Dynamics Using Ultrasound Imaging

The paper develops a brachial artery relaxation index (BARI) to predict abdominal aortic aneurysm (AAA) growth but finds no significant correlation between BARI and future AAA growth.

Vascular origins of low-frequency oscillations in the cerebrospinal fluid signal in resting-state fMRI: Interpretation using photoplethysmography

This study investigates the relationship between low-frequency cerebrospinal fluid (CSF) oscillations and vascular signals using resting-state fMRI and photoplethysmography, finding that vascular contributions vary across CSF regions and that PIR is more strongly associated with CSF signals than PPG.

Genetic similarity and facial cues for kin recognition in humans

The paper investigates the relationship between perceived facial similarity and genetic markers in humans, finding that HLA allelic sharing correlates with perceived self-resemblance, while other markers like microsatellites and mitochondrial haplogroups do not.

Quantitative Imaging of Receptor-Ligand Engagement in Intact Live Animals

This study develops MFLI-FRET to quantify receptor-ligand engagement in live animals, showing it correlates with intracellular ligand binding rather than ex vivo receptor expression.