M. Barroso

Contrast-enhanced photon-counting micro-CT of tumor xenograft models

This study evaluates contrast agents for photon-counting micro-CT in tumor xenografts, finding that Exitrone Nano 12000 provides better vasculature enhancement and consistency compared to ISOVUE-370.

Fluorescence Lifetime Imaging for Quantification of Targeted Drug Delivery in Varying Tumor Microenvironments

This study uses fluorescence lifetime imaging to quantify TZM-HER2 binding and distribution in tumors with varying microenvironments, showing differences in drug delivery efficacy between cancer types.

Nuclear cytoglobin associates with HMGB2 and regulates DNA damage and genome-wide transcriptional output in the vasculature

This study identifies nuclear cytoglobin's role in regulating DNA damage and transcriptional output in vascular smooth muscle cells through its interaction with HMGB2.

in vivo quantitative FRET small animal imaging: intensity versus lifetime-based FRET

This paper compares intensity-based and fluorescence lifetime-based FRET methods for in vivo small animal imaging, showing that lifetime-based FRET is more efficient and accurate for quantifying drug-target engagement.

DMT1 bridges endosomes and mitochondria to modulate mitochondrial iron translocation

This study shows DMT1 modulates mitochondrial iron translocation in invasive breast cancer cells by bridging endosomes and mitochondria, affecting iron levels and mitochondrial function.

In vitro and in vivo NIR Fluorescence Lifetime Imaging with a time-gated SPAD camera

This study demonstrates the use of a time-gated SPAD camera for in vitro and in vivo NIR fluorescence lifetime imaging, showing its effectiveness in monitoring molecular events in tumor xenografts.

Deep Learning Enhanced Hyperspectral Fluorescence Lifetime Imaging

This paper introduces a deep learning framework for fast hyperspectral fluorescence lifetime imaging, achieving rapid acquisition and processing without training data.

Multiplexed Non-invasive in vivo Imaging to Assess Metabolism and Receptor Engagement in Tumor Xenografts

This paper develops a multiplexed imaging method to simultaneously assess tumor metabolism and receptor engagement in vivo, revealing an inverse relationship between metabolic activity and drug delivery efficacy.

Ultra-fast fit-free analysis of complex fluorescence lifetime imaging via deep learning

This paper introduces FLI-Net, a deep learning model that enables ultra-fast, fit-free analysis of fluorescence lifetime imaging data across multiple spectral ranges and acquisition technologies.

In vitro and in vivo phasor analysis of stoichiometry and pharmacokinetics using short lifetime near-infrared dyes and time-gated imaging

The paper introduces a method using phasor analysis and NIR dyes to quantify fluorescence lifetime and stoichiometry in vitro and in vivo, demonstrating its application to FRET and pharmacokinetics studies.

Quantitative Imaging of Receptor-Ligand Engagement in Intact Live Animals

This study develops MFLI-FRET to quantify receptor-ligand engagement in live animals, showing it correlates with intracellular ligand binding rather than ex vivo receptor expression.