J. J. Chen

Simulation-based dosimetry of transcranial and intranasal photobiomodulation of the human brain: the roles of wavelength, power density and skin colour

This study uses Monte Carlo simulations to investigate how wavelength, power density, and skin colour affect light penetration and energy accumulation in transcranial and intranasal photobiomodulation of the human brain.

Predicting the macrovascular contribution to resting-state fMRI functional connectivity at 3 Tesla: A model-informed approach

This paper demonstrates the feasibility of predicting resting-state fMRI functional connectivity and BOLD fluctuation amplitudes using biophysical models of macrovascular anatomy at 3 Tesla.

BOLDsωimsuite: A new software suite for forward modeling of the BOLD fMRI signal

This paper introduces BOLDswimsuite, an open-source Python toolbox for forward modeling of the BOLD fMRI signal, providing modular components and flexibility for simulations.

Discovery of CMX990: A Potent SARS-CoV-2 3CL Protease Inhibitor Bearing a Novel Covalent Warhead

This paper introduces CMX990, a potent SARS-CoV-2 3CL protease inhibitor with improved potency and clearance compared to nirmatrelvir, advancing to Phase 1 clinical trials.

Assessment of the macrovascular contribution to resting-state fMRI functional connectivity at 3 Tesla

This study assesses the macrovascular contribution to resting-state fMRI functional connectivity, finding strong correlations between large veins and arteries and demonstrating their significant impact on whole-GM connectivity.

Histone H1.0 Couples Cellular Mechanical Behaviors to Chromatin Structure

This study shows that histone H1.0 regulates cellular mechanical behaviors by controlling chromatin structure and gene expression in response to extracellular stress.

Sensitivity of diffusion-tensor and correlated diffusion imaging to white-matter microstructural abnormalities: application in COVID-19

This study compares diffusion MRI methods to detect white-matter changes in COVID-19 patients, finding correlated diffusion imaging is most sensitive to microstructural abnormalities.

Modeling the carbon-dioxide response function in fMRI under task and resting-state conditions

This paper compares model-based deconvolution methods for estimating dCVR in fMRI under various noise conditions and identifies the most accurate and efficient approach.

Vascular origins of low-frequency oscillations in the cerebrospinal fluid signal in resting-state fMRI: Interpretation using photoplethysmography

This study investigates the relationship between low-frequency cerebrospinal fluid (CSF) oscillations and vascular signals using resting-state fMRI and photoplethysmography, finding that vascular contributions vary across CSF regions and that PIR is more strongly associated with CSF signals than PPG.

Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer

This study identifies LXRalpha as a driver of chemoresistance in TNBC through its regulation of P-glycoprotein, linking cholesterol metabolism to chemotherapy failure.

Suppressors of YpsA-mediated cell division inhibition in Bacillus subtilis

This study identifies suppressor mutations in Bacillus subtilis that alleviate YpsA-mediated cell division inhibition, revealing YfhS's role in cell size regulation.

Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation

The paper identifies ESCRT pathway components as regulators of tau aggregation propagation by enabling endolysosomal escape of tau seeds.

Magnetic Resonance Fingerprinting with Combined Gradient- and Spin-echo Echo-planar Imaging: Simultaneous Estimation of T1, T2 and T2* with integrated-B1 Correction

This paper introduces a magnetic resonance fingerprinting framework combining gradient- and spin-echo echo-planar imaging to simultaneously estimate T1, T2, and T2* with integrated B1 correction, showing high accuracy in phantom and human scans.

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide are Potent TMEM16A Antagonists that Fully Bronchodilate Airways

This paper identifies niclosamide and nitazoxanide as potent TMEM16A antagonists that fully bronchodilate airways, offering new treatment options for severe asthma and COPD.

The palmitoyl acyltransferase DHHC5 mediates beta-adrenergic signaling in the heart by targeting Gα proteins and G protein-coupled receptor kinase 2

This study shows that DHHC5 mediates beta-adrenergic signaling in the heart by palmitoylating Gα proteins and GRK2, essential for downstream functional responses.