Mechanistic insights and clinical implications of cross-reactive anti-prophage antibodies and bacterial heteroresistance on phage therapeutic failure
Fernando L. Gordillo Altamirano, Dinesh Subedi, Mariel Beiers, Michael J Bucher, Sofia Dahlman, Devang M. Patel, M. Parker, Denis Korneev, Marcus J Robinson, Katherine Pragastis, J. Wisniewski, C. Rees, Hayley S. Ramshaw, Sadid F Khan, Bradley J. Gardiner, , Anton Yariv Peleg
The paper identifies pre-existing anti-prophage antibodies and bacterial heteroresistance as factors contributing to phage therapy failure in a patient with chronic infection.
Nature Medicine · Apr 24, 2026Peer-reviewedMicrobiology