M. Parker

Mechanistic insights and clinical implications of cross-reactive anti-prophage antibodies and bacterial heteroresistance on phage therapeutic failure

The paper identifies pre-existing anti-prophage antibodies and bacterial heteroresistance as factors contributing to phage therapy failure in a patient with chronic infection.

Evaluation of the accuracy of bacterial genome reconstruction with Oxford Nanopore R10.4.1 long-read-only sequencing

This paper evaluates the accuracy of bacterial genome reconstruction using Oxford Nanopore R10.4.1 long-read-only sequencing and finds it produces accurate assemblies at 40x depth, competitive with hybrid Illumina-Nanopore assemblies.

Dysregulated expression of Hoxa1 isoforms in hematopoietic stem and progenitor cells causes myelodysplastic syndromes.

This study shows that dysregulated Hoxa1 isoforms in hematopoietic stem and progenitor cells cause myelodysplastic syndromes and provide mouse models for disease progression.

Mutation-specific pathophysiological mechanisms define different neurodevelopmental disorders associated with SATB1 dysfunction

The paper identifies mutation-specific pathophysiological mechanisms in SATB1 variants causing distinct neurodevelopmental disorders.

Cyclic gallium-68 labeled peptides for specific detection of human angiotensin-converting enzyme 2

This paper develops 68Ga-labeled cyclic peptides derived from ACE2 inhibitor DX600 to detect ACE2 expression in vivo, showing specific binding in organs affected by SARS-CoV-2.

Global cropland connectivity: A risk factor for invasion and saturation by emerging pathogens and pests

The paper assesses global cropland connectivity networks for key crops to identify high-risk areas for pathogen and pest spread, integrating this with other factors for pest risk assessment.