Author

R. Pan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Immunology· 2 Biochemistry· 1 Bioengineering· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Organism:chicken / avian· 1

Frequent Co-Authors

H. Liu· 2 shared J. Chen· 2 shared K. Ozato· 2 shared X. Wu· 2 shared Y. Wang· 2 shared A. Dey· 1 shared B. H. Hayes· 1 shared B. Ni· 1 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersImmunology

H. Liu

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Cell-autonomous targeting of arabinogalactan by host immune factors inhibits mycobacterial growth

L. Qin, J. Xu, J. Chen, S. Wang, R. Zheng, Z. Cui, Z. Liu, X. Wu, J. Wang, X. Huang, Z. Wang, M. Wang, R. Pan, S. H. Kaufmann, X. Meng, , H. Liu

The paper identifies galectin-9 and AG-specific antibodies that inhibit Mtb growth by targeting arabinogalactan, offering a new immunotherapeutic strategy for TB.

bioRxiv · Oct 5, 2023Immunology

BRD4 directs mitotic cell division by inhibiting DNA damage

T. Wu, H. Hou, A. Dey, M. Bachu, X. Chen, J. Wisniewski, F. Kudoh, C. Chen, S. Chauhan, H. Xiao, R. Pan, K. Ozato

This study shows BRD4 is essential for normal cell growth by regulating cell cycle genes and preventing DNA damage during replication and mitosis.

bioRxiv · Jul 2, 2023 · PreprintCell Biology

IRF8 configures enhancer landscape in postnatal microglia and directs microglia specific transcriptional programs

K. Saeki, R. Pan, E. Lee, D. Kurotaki, K. Ozato

This study shows IRF8 regulates enhancer landscapes and transcriptional programs in postnatal microglia, affecting their identity and response to disease.

bioRxiv · Jun 25, 2023Immunology

Evolution of the gene regulatory network of body axis by enhancer hijacking in amphioxus

C. Shi, S. Chen, H. Liu, S. Li, Y. Wang, R. Pan, X. Wu, X. Li, J. Li, C. Xing, X. Liu, Y. Wang, Q. Qu, G. Li

The paper investigates the evolution of a gene regulatory network in amphioxus, showing that enhancer hijacking allowed a new GRN to emerge through the functional shift of Gdf1/3-like to replace Gdf1/3 in axial development.

bioRxiv · Jun 11, 2023Evolutionary Biology

An e-cigarette aerosol generation, animal exposure and toxicants quantification system to characterize in vivo nicotine kinetics in arterial and venous blood

J. Zhang, M. Xue, R. Pan, Y. Zhu, Z. Zhang, H. Cheng, J. L. M. Björkegren, J. Chen, Z. Shi, K. Hao

This paper describes a system for generating and assessing e-cigarette aerosol exposure in animals, showing higher nicotine concentrations in arterial blood compared to venous blood.

bioRxiv · Oct 12, 2022 · PreprintPharmacology & Toxicology

PanGu Drug Model: Learn a Molecule Like a Human

X. Lin, C. Xu, Z. Xiong, X. Zhang, N. Ni, B. Ni, J. Chang, R. Pan, Z. Wang, F. Yu, H. Jiang, M. Zheng, N. Qiao

The paper introduces PanGu Drug Model, a deep learning architecture for drug discovery that achieves state-of-the-art results in molecule property prediction, generation, and optimization.

bioRxiv · Mar 31, 2022Biochemistry

Engineering bacterial blight-resistant plants through CRISPR/Cas9-targeted editing of the MeSWEET10a promoter in cassava

Y. Wang, M. Geng, R. Pan, T. Zhang, X. Lu, X. Zhen, Y. Che, R. Li, J. Liu, Y. Chen, J. Guo, Y. Yao

This study edits the MeSWEET10a promoter in cassava to confer resistance to bacterial blight without affecting yield traits.

bioRxiv · Mar 2, 2022 · PreprintPlant Biology

Cooperative phagocytosis underlies macrophage immunotherapy of solid tumours and initiates a broad anti-tumour IgG response

J. C. Andrechak, L. J. Dooling, B. H. Hayes, S. Kadu, W. Zhang, R. Pan, M. Vashisth, J. Irianto, C. M. Alvey, D. E. Discher

This study shows engineered macrophages using cooperative phagocytosis eliminate solid tumours and induce anti-tumour IgG, improving immunotherapy outcomes.

bioRxiv · Jan 1, 2022Bioengineering

An updated assembly strategy helps parsing the cryptic mitochondrial genome evolution in plants

Y. Feng, X. Xiang, Z. Fu, R. Pan, X. Jin

The paper develops a new assembly strategy to improve mitogenome reconstruction in plants, revealing mosaic structures and horizontal transfer contributions to mitochondrial evolution.

bioRxiv · Mar 2, 2021 · PreprintEvolutionary Biology