H. Hou

BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor

This study shows that FHD-286, a BRG1/BRM inhibitor, reduces AML burden and improves survival when combined with Menin or BET inhibitors in xenograft models of AML with MLL1r or mtNPM1.

BRD4 directs mitotic cell division by inhibiting DNA damage

This study shows BRD4 is essential for normal cell growth by regulating cell cycle genes and preventing DNA damage during replication and mitosis.

Water wisteria genome reveals environmental adaptation and heterophylly regulation in amphibious plants

This study sequenced the genome of water wisteria, revealing genes and pathways involved in its environmental adaptation and leaf shape changes.

Chromosome-level genome assembly of Rorippa aquatica revealed its allotetraploid origin and mechanisms of heterophylly upon submergence

This study assembled the chromosome-level genome of Rorippa aquatica to investigate its allotetraploid origin and the molecular mechanisms of heterophylly under submergence.

MOLECULAR VIDEOGAMING: SUPER-RESOLVED TRAJECTORY-BASED NANOCLUSTERING ANALYSIS USING SPATIO-TEMPORAL INDEXING

The paper introduces a new method to analyze SMLM data by incorporating temporal information, revealing transient nanoclusters of syntaxin1a and Munc18-1 on the plasma membrane.

Combinatorial approaches using an AI/ML-driven drug development platform targeting insulin resistance, lipid dysregulation, and inflammation for the amelioration of metabolic syndrome in patients

The paper proposes a combinatorial drug approach using FDA-approved compounds targeting IL-17a and DPP4 to treat metabolic syndrome, using an AI/ML platform to identify promising drug candidates.

COVID-ONE-humoral immune: The One-stop Database for COVID-19-specific Antibody Responses and Clinical Parameters

The paper introduces a database that compiles antibody responses and clinical data from COVID-19 patients for analysis and visualization.

Undergraduate student interest in healthcare career in the context of COVID-19 pandemic

This study assesses changes in undergraduate student interest in healthcare careers during the COVID-19 pandemic using a survey of 297 students, finding increased interest despite pandemic challenges.

Sulfur limitation increases duckweed starch accumulation without compromising growth

This study shows sulfur limitation increases duckweed starch yield without reducing growth, making it a promising method for biofuel production.

Alternative polyadenylation is a determinant of oncogenic Ras function

This study shows that alternative polyadenylation regulates oncogenic Ras function by affecting transcript 3' UTR length in both C. elegans and human cells.

Structural insight into the mechanism of 4-aminoquinolines selectivity for the alpha2A-adrenoceptor

This study investigates the selectivity of 4-aminoquinolines for the alpha2A-adrenoceptor using docking, molecular dynamics, and mutagenesis to identify binding sites and affinity determinants.