Platelet-Localized ST6Gal1 Does Not Impact IgG Sialylation
L. M. Glendenning, J. Y. Zhou, E. N. Kukan…·B. A. Cobb
This study investigates whether platelet-localized ST6Gal1 affects IgG sialylation and finds no significant impact.
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5 papers
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L. M. Glendenning, J. Y. Zhou, E. N. Kukan…·B. A. Cobb
This study investigates whether platelet-localized ST6Gal1 affects IgG sialylation and finds no significant impact.
L. M. Glendenning, J. Y. Zhou, K. M. Reynero, B. A. Cobb
This study shows that IgG sialylation and fucosylation diverge from B cell surface glycoprotein modification, with IgG avoiding sialylation and favoring fucosylation due to distinct trafficking patterns.
D. M. Oswald, S. D. Lehoux, J. Y. Zhou…·B. A. Cobb
The paper shows that plasma ST6Gal1 is not required for IgG 2,6-sialylation, as IgG sialylation remains normal in mice lacking ST6Gal1 in hepatocytes or B cells.
E. D. Sorelle, J. Dai, J. Y. Zhou…·M. A. Luftig
This study uses single-cell RNA sequencing to analyze transcriptomic heterogeneity in lymphoblastoid cell lines and shows how stochastic factors influence clonal evolution.
J. Y. Zhou, C. A. Alvarez, B. A. Cobb
This study shows that regulatory T cells integrate IL-2 and IL-4 signals to produce a response distinct from individual cytokine effects, enhancing IL-10 production and therapeutic outcomes in mouse models of asthma and multiple sclerosis.