J. Dai

High-throughput drug screening for inhibition of influenza A virus infection based on human SIRT1 promoter and Genipin suppressing influenza A virus by activation of AMPK-SIRT1-PGC-1α signaling pathway

This study identifies Genipin and its derivatives as inhibitors of influenza A virus replication by activating the AMPK-SIRT1-PGC-1α signaling pathway and altering metabolic reprogramming.

Development of an engineered extracellular vesicles-based vaccine platform for combined delivery of mRNA and protein to induce functional immunity

This paper develops an engineered extracellular vesicles-based vaccine platform for combined mRNA and protein delivery, showing tumor regression and immune responses in preclinical models.

A 10-valent composite mRNA vaccine against both influenza and COVID-19

This paper introduces FLUCOV-10, a 10-valent mRNA vaccine targeting influenza and SARS-CoV-2, showing robust immune responses and complete protection in mice against multiple strains.

Efficient overexpression and purification of SARS-CoV-2 Nucleocapsid proteins in Escherichia coli

The paper describes the scalable production and purification of SARS-CoV-2 nucleocapsid proteins in E. coli and evaluates their use in ELISA assays.

Is M1-L121E a good mimic on microbial rhodopsin? A viewpoint from excited-state dynamics

This paper investigates the excited-state dynamics of a microbial rhodopsin mimic, M1-L121E, and finds it captures key features but shows distinct differences in photoreaction dynamics compared to natural rhodopsin.

The Unexpected Role of GCN2 Kinase Activation in Mediating Pulmonary Vascular Remodeling and Pulmonary Arterial Hypertension

This study shows GCN2 kinase activation in hypoxia mediates pulmonary vascular remodeling and PAH via Edn1, suggesting GCN2 as a therapeutic target for PAH.

Learning induced neuronal identity switch in the superficial layers of the primary somatosensory cortex

This study identifies a learning-induced neuronal identity switch in the primary somatosensory cortex of mice during trace eyeblink conditioning.

Distinct Microstructural Heterogeneities Underpin Specific Micromechanical Properties in Human ACL Femoral and Tibial Entheses

This study identifies distinct microstructural and biomolecular features in ACL femoral and tibial entheses that contribute to their specific mechanical properties.

Targeting CD301+ macrophage inhibits endometrial fibrosis and improves pregnancy outcome

This study identifies CD301+ macrophages as drivers of endometrial fibrosis and infertility, showing their inhibition improves pregnancy outcomes in mice.

Mutation Patterns Predict Drug Sensitivity in Acute Myeloid Leukemia

The paper identifies mutation patterns linked to drug sensitivity in AML using integrated computational and experimental analysis.

Membrane-remodeling protein ESCRT-III homologs incarnate the evolution and morphogenesis of multicellular magnetotactic bacteria

This study identifies ESCRT-III homologs in magnetotactic bacteria, showing their role in membrane remodeling and multicellular morphogenesis through genomic and imaging analyses.

A membrane-associated light harvesting model is enabled by functionalized assemblies of gene-doubled TMV proteins

This paper develops a synthetic light harvesting model using modified TMV proteins attached to lipid bilayers, enabling dynamic energy transfer studies.

Rotavirus NSP1 subverts the antiviral OAS-RNase L pathway by inducing RNase L degradation

This study identifies a novel mechanism by which rotavirus NSP1 subverts the OAS-RNase L antiviral pathway by inducing RNase L degradation through ubiquitination.

Stability of SARS-CoV-2 in cold-chain transportation environments and the efficacy of disinfection measures

This study investigates how cold-chain conditions and disinfection methods affect SARS-CoV-2 stability, finding that low temperature and seawater increase viral survival while LED light and airflow reduce it.

Vitamin C is an efficient natural product for prevention of SARS-CoV-2 infection by targeting ACE2 in both cell and in vivo mouse models

This paper shows that Vitamin C reduces ACE2 protein levels and blocks SARS-CoV-2 infection in cell and mouse models by inhibiting USP50-ACE2 interaction.

Tracing back primed resistance in cancer via sister cells

The paper introduces ReSisTrace, a method to identify pre-resistant cell states in cancer by analyzing sister cells, and validates its use in ovarian cancer models.

TLR4 signaling in presence of HIV-induced activation enhances programmed death ligand-1 expression on human plasmacytoid dendritic cells and modulates their function

This study shows that TLR4 signaling in HIV-infected individuals enhances PD-L1 expression and modulates pDC function, contributing to immune suppression.

Fate-resolved gene regulatory signatures of individual B lymphocytes in the early stages of Epstein-Barr Virus infection

This paper uses single-cell transcriptomics and chromatin accessibility to model early EBV infection dynamics and identifies regulatory signatures in B lymphocytes.

Chlamydomonas ARMC2/PF27 is an obligate cargo adapter for IFT of radial spokes

The paper identifies ARMC2/PF27 as a specific cargo adapter required for IFT of radial spokes in Chlamydomonas, ensuring their assembly along flagella.

Extrachromosomal Amplification of Human Papillomavirus Episomes as a Mechanism of Cervical Carcinogenesis

The paper identifies extrachromosomal HPV16 episomes as a mechanism of cervical carcinogenesis, showing that they can cause cancer without integration through rearranged and multimer episomes.

Endothelial PHD2 Deficiency Induces Nitrative Stress via Suppression of Caveolin-1 in Pulmonary Arterial Hypertension

This study shows that endothelial PHD2 deficiency leads to nitrative stress via suppression of Caveolin-1, contributing to pulmonary arterial hypertension and vascular remodeling.

ASFV pD345L protein negatively regulates NF-kB signaling through inhibiting IKK kinase activity

This study identifies pD345L as an ASFV protein that inhibits NF-κB signaling by blocking IKK kinase activity, providing insights into ASFV immune evasion mechanisms.

Development of a Novel PROTAC using the Nucleic Acid Aptamer as a Targeting Ligand for Tumor Selective Degradation of Nucleolin

This paper develops a novel PROTAC, ZL216, using an aptamer as a targeting ligand to selectively degrade nucleolin in breast cancer cells, inhibiting their proliferation and migration.

Hexapeptide induces M2 macrophage polarization via the JAK1/STAT6 pathway to promote angiogenesis in bone repair

This study shows that the hexapeptide WKYMVm promotes M2 macrophage polarization via the JAK1/STAT6 pathway, enhancing angiogenesis in bone repair.

The compound of baicalein, wogonin, and oroxylin-A inhibits EMT in A549 cell line via PI3K/AKT-TWIST1-glycolysis pathway

This study identifies baicalein, wogonin, and oroxylin-A as active compounds in TFAE that inhibit EMT in A549 cells via the PI3K/AKT-TWIST1-glycolysis pathway.

A spatial and cellular distribution of neurotropic virus infection in the mouse brain revealed by fMOST and single cell RNA-seq

This study uses fMOST and scRNA-seq to map the spatial and cellular distribution of rabies virus in the mouse brain, revealing infection in multiple nuclei and non-neuronal cells.

DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer

This study shows UV-nail polish dryer radiation causes DNA damage and somatic mutations in mammalian cells, with mutagenic patterns linked to reactive oxygen species.

ATGs ubiquitination is required for circumsporozoite protein to subvert host innate immunity against malaria liver stage

The paper shows that CSP reduces ATG levels via ubiquitination by NEDD4, enabling EEFs to evade IFN-gamma-mediated killing in hepatocytes.

The female urinary microbiota in relation to the reproductive tract microbiota

The study analyzes the urinary microbiota of 147 Chinese women, revealing non-sterile urine with distinct bacterial communities and showing similarity to cervical and uterine microbiota rather than vaginal microbiota.

Hydrogel-coating improves the in-vivo stability of electrochemical aptamer-based biosensors

This paper demonstrates that hydrogel-coating enhances the in vivo stability of electrochemical aptamer-based biosensors without compromising detection performance.