Author

J.-A. Sahel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 5 Animal Behavior & Cognition· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 7 Approach:experimental assay· 6 Organism:human· 6 Assay:imaging· 4 Research Focus:differential expression· 3 Research Focus:clustering· 2 Research Focus:imputation· 2 Organism:non-human primate· 2

Frequent Co-Authors

E. A. Rossi· 3 shared E. Gofas· 3 shared M. Zhang· 3 shared P. Mece· 3 shared Y. Rui· 3 shared K. Grieve· 2 shared M.-H. Errera· 2 shared S. Picaud· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBioengineering

E. A. Rossi

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in atrophic AMD

S. Ghosh, R. Sharma, S. Bammidi, V. Koontz, M. Nemani, M. Yazdankhah, K. M. Kedziora, C. T. Wallace, C. Yu-Wei, J. Franks, D. Bose, D. Rajasundaram, S. Hose, J.-A. Sahel, R. Puertollano, , D. Sinha

This study identifies the AKT2/SIRT5/TFEB pathway as a therapeutic target for atrophic AMD by showing its role in lysosomal dysfunction and drusen formation in RPE cells.

bioRxiv · Aug 8, 2023 · PreprintCell Biology

Imaging the structure and dynamic activity of retinal microglia and macrophage-like cells in the living human eye

Y. Rui, D. M. W. Lee, M. Zhang, V. C. Snyder, R. Raghuraman, E. Gofas, P. Mece, S. Yadav, K. Grieve, J.-A. Sahel, M.-H. Errera, E. A. Rossi

This paper introduces a fiber-bundle adaptive optics scanning light ophthalmoscopy (FB-AOSLO) method to image retinal microglia and macrophage-like cells in living eyes, showing increased speed and dynamic activity monitoring.

bioRxiv · Apr 30, 2022 · PreprintBioengineering

IMMMUNE MEDIATORS IN IDIOPATHIC UVEITIS

M.-H. Errera, A. Pratas, S. Fisson, T. Manicom, M. Boubaya, N. Sedira, E. Heron, L. Merabet, A. Kobal, V. Levy, J.-M. Warnet, C. Chaumeil, F. Brignole-Baudouin, J.-A. Sahel, P. Goldschmidt, , C. Bloch-Queyrat

This study identifies elevated proinflammatory cytokines and chemokines in idiopathic uveitis compared to controls and identifies distinct subgroups based on cytokine profiles.

bioRxiv · Aug 4, 2021 · PreprintImmunology

Spatial frequency-based image reconstruction to improve image contrast in multi-offset adaptive optics ophthalmoscopy

P. Mece, E. Gofas, Y. Rui, M. Zhang, J.-A. Sahel, E. A. Rossi

The paper introduces a post-processing method to enhance retinal image contrast by optimally combining multi-offset AO ophthalmoscope images.

Optics Letters · Mar 1, 2021Peer-reviewedBioengineering

Design of a radial multi-offset detection pattern for in vivo phase contrast imaging of the retinal ganglion cells in humans

E. Gofas, Y. Rui, P. Mece, M. Zhang, V. C. Snyder, K. V. Vienola, D. Lee, J.-A. Sahel, K. Grieve, E. A. Rossi

This paper designs a radial multi-offset detection pattern for in vivo phase contrast imaging of human retinal ganglion cells, achieving improved contrast and robustness compared to previous methods.

bioRxiv · Dec 8, 2020 · PreprintBioengineering

scAAVengr: Single-cell transcriptome-based quantification of engineered AAVs in non-human primate retina

B. E. Ozturk, M. E. Johnson, M. Kleyman, S. Turunc, J. He, S. Jabalameli, Z. Xi, M. Visel, V. L. Dufour, S. Iwabe, F. Pompeo Marinho, G. D. Aguirre, J.-A. Sahel, D. V. Schaffer, A. R. Pfenning, , L. C. Byrne

The paper develops scAAVengr, a single-cell pipeline to quantify AAV gene expression efficiency in non-human primate retina, demonstrating its utility with a top-performing AAV variant.

bioRxiv · Oct 1, 2020 · PreprintBioengineering

Ultrasound functional neuroimaging reveals propagation of task-related brain activity in behaving primates

A. Dizeux, M. Gesnik, H. Ahnine, K. Blaize, F. Arcizet, S. Picaud, J.-A. Sahel, T. Deffieux, P. Pouget, M. Tanter

This paper demonstrates that neurofunctional ultrasound imaging can capture task-related brain activity and its propagation in behaving primates with high spatiotemporal resolution.

bioRxiv · Nov 7, 2018Animal Behavior & Cognition

Restoration of visual function by transplantation of optogenetically engineered photoreceptors

M. Garita-Hernandez, M. Lampic, A. Chaffiol, L. Guibbal, F. Routet, T. Santos-Ferreira, G. Gagliardi, S. Reichman, S. Picaud, J.-A. Sahel, O. Goureau, M. Ader, D. Dalkara, J. Duebel

This study shows that transplanting optogenetically engineered photoreceptors can restore visual function in blind mice through light-responsive responses at multiple retinal levels.

bioRxiv · Aug 29, 2018Bioengineering