D. Bose

TGF-β blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo

TGF-β blockade with galunisertib reverses SIV latency, reduces viral reservoirs, and enhances immune responses in ART-treated macaques without systemic inflammation.

The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in atrophic AMD

This study identifies the AKT2/SIRT5/TFEB pathway as a therapeutic target for atrophic AMD by showing its role in lysosomal dysfunction and drusen formation in RPE cells.

Decoding Sequence-Structure-Function-Evolution of basic Leucine Zippers of Aureochromes from Heterokont Algae

This study investigates the sequence, structure, and function of Aureochrome bZIP domains using computational and experimental methods, revealing unique features in DNA binding and evolutionary significance.

Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo

This study shows that blocking TGF-β signaling increases HIV-1 and SIV reactivation and boosts immune responses in infected individuals on ART.

Prior exposure to microcystin alters host gut resistome and is associated with dysregulated immune homeostasis in translatable mouse models

This study shows that microcystin exposure alters the gut resistome and dysregulates immune homeostasis in mice, linking antibiotic resistance genes to immune markers.

Erythroid spectrin binding modulates peroxidase and catalase activity of heme proteins

This study shows that spectrin binding modulates peroxidase activity of hemoglobin and other heme proteins, with implications for oxidative damage in diseases like sickle cell disease.

Spectrin Interactome under normal and HbE-disease conditions

The paper reports the first interactome of human erythroid spectrin and finds no change in interacting protein identity but altered abundance under HbE disease conditions, with increased redox and chaperone proteins.

Interaction of NPC2 protein with Lysobisphosphatidic Acid is required for normal endolysosomal cholesterol trafficking

The paper shows NPC2 interacts with LBPA to facilitate cholesterol trafficking from late endosomes/lysosomes, independent of NPC1.

Localizing the chaperone activity of erythroid spectrin

This study identifies hydrophobic surface patches on spectrin domains as the source of its chaperone activity, showing that all domains contribute equally to this function.