E. Roberts

Arterial mechanics, extracellular matrix, and smooth muscle differentiation in carotid arteries deficient for Rac1

This study investigates whether Rac1 deletion affects SMC proliferation by altering arterial stiffness or differentiation, finding no significant changes in ECM composition, stiffness, or SMC markers.

ERBB signalling contributes to immune evasion in KRAS-driven lung adenocarcinoma

The paper investigates how ERBB signaling contributes to immune evasion in KRAS-driven lung adenocarcinoma using a novel mouse model and finds that transient ERBB blockade can restore immune surveillance when combined with PD1 blockade.

Evidence for deliberate burial of the dead by Homo naledi

This study presents evidence for deliberate burial of Homo naledi remains in South Africa's Rising Star cave system, suggesting mortuary behavior in this species.

Development of allosteric, selective cyclin-dependent kinase 2 (CDK2) inhibitors that are negatively cooperative with cyclin binding and show potential as contraceptive agents

This paper develops high-affinity, structurally confirmed allosteric CDK2 inhibitors that show negative cooperativity with cyclin binding and demonstrate contraceptive potential in mouse testicular explants.

Superinfection exclusion creates spatially distinct influenza virus populations

This study shows that superinfection exclusion (SIE) creates spatially distinct influenza virus populations, limiting genome interactions between virus subpopulations as they spread within host tissues.

PP6 regulation of Aurora A-TPX2 limits NDC80 phosphorylation and mitotic spindle size

The paper shows that PP6 regulates Aurora A-TPX2 to control NDC80 phosphorylation and mitotic spindle size, preventing defective nuclear structure.

MPS1 localizes to microtubule-attached kinetochores and actively promotesmicrotubule release

The paper shows MPS1 localizes to microtubule-attached kinetochores and actively promotes microtubule release, challenging the model of MPS1 as a passive sensor.

Urine-derived exosomes from individuals with IPF carry pro-fibrotic cargo.

The paper shows urine-derived exosomes from IPF patients carry pro-fibrotic miRNAs that induce fibrosis in skin and lung models.

A spatial stochastic model reveals the role of supercoiling in transcription regulation

This paper develops a spatial stochastic model to show how supercoiling affects transcription regulation in E. coli by enabling communication between RNA polymerase molecules and coordinating gene expression.

Efemp1 modulates elastic fiber formation and mechanics of the extrahepatic bile duct

This study shows EFEMP1 is crucial for elastic fiber formation and mechanical properties of the extrahepatic bile duct, with reduced EFEMP1 leading to increased compliance and potential role in biliary atresia.

RAGE antagonist peptide mitigates AGE-mediated endothelial hyperpermeability and accumulation of glycoxidation products in human ascending aortas and in a murine model of aortic aneurysm

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp14/nsp10 Exoribonuclease

This study identifies patulin and aurintricarboxylic acid as inhibitors of SARS-CoV-2 nsp14 exoribonuclease, showing antiviral activity in cell culture.

Identification of SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of the nsp14 RNA Cap Methyltransferase

This study identifies four small molecule inhibitors of SARS-CoV-2 nsp14 RNA cap methyltransferase, with three showing synergy with remdesivir in antiviral assays.

Measurement of Klebsiella Intestinal Colonization Density to Assess Infection Risk

This study develops a qPCR assay to measure Klebsiella colonization density in rectal swabs and finds that higher density is significantly associated with increased infection risk.

Learned adaptive multiphoton illumination microscopy

This paper develops a machine learning model to adaptively adjust multiphoton microscopy illumination power based on in situ cell imaging, enabling improved in vivo immune response visualization in mouse lymph nodes.

A Pairwise Distance Distribution Correction (DDC) algorithm to eliminate blinking-caused artifacts in super-resolution microscopy

The paper introduces DDC, a method to correct blinking artifacts in SMLM by using true pairwise distance distributions, improving spatial reconstruction accuracy.

Automatic error control during forward flux sampling of rare events in master equation models

This paper introduces FFPilot, a method to control sampling error in forward flux sampling simulations, achieving efficient error control across multiple dimensions.

Reconstructing an epigenetic landscape using a genetic ‘pulling’ approach

This paper introduces a nonequilibrium perturbation method to reconstruct epigenetic landscapes using simulated data, showing that accurate representations can be recovered with few experiments.

WRN Helicase is a Synthetic Lethal Target in Microsatellite Unstable Cancers

The paper identifies WRN helicase as a synthetic lethal target in microsatellite unstable cancers through CRISPR/Cas9 and RNAi screens, showing its essentiality in MSI cell lines.

Neural network control of focal position during time-lapse microscopy of cells

The paper develops a neural network to maintain focus during live-cell microscopy, achieving sub-micron accuracy and robustness in long-term experiments.