Author

K. Alexander

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Pettit· 2 shared B. Jose· 2 shared D. Girard· 2 shared F. Genet· 2 shared H.-W. Tseng· 2 shared J. Gueguen· 2 shared J.-P. Levesque· 2 shared M. Salga· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPathology

A. Pettit

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Targeting phosphoRab-RILPL Interactions as a Strategy to Downregulate Pathogenic LRRK2 in Parkinson's Disease

K. Alexander, Y. Naaldijk, R. Fasiczka, B. Brahmia, T. Chen, S. Hilfiker, E. J. Kennedy

This paper demonstrates that constrained peptides mimicking phosphorylated Rab8 can block RILPL interactions and restore ciliogenesis and centrosomal cohesion defects in cells with mutant LRRK2.

bioRxiv · Nov 6, 2023Biochemistry

Spinal cord injury reprograms muscle fibro-adipogenic progenitors to formheterotopic bones within muscles

H.-W. Tseng, D. Girard, K. Alexander, S. Millard, F. Torossian, A. Anginot, W. Fleming, J. Gueguen, M.-E. Goriot, D. Clay, B. Jose, B. Nowlan, A. Pettit, M. Salga, F. Genet, , J.-P. Levesque

This study identifies fibro-adipogenic progenitors (FAPs) as the cells-of-origin for neurogenic heterotopic ossifications (NHO) following spinal cord injury, showing their reprogramming into osteoblasts.

bioRxiv · Nov 4, 2021 · PreprintPathology

Interleukin-1 is overexpressed in injured muscles following spinal cord injury and promotes neurogenic heterotopic ossification

H.-W. Tseng, I. Kulina, D. Girard, J. Gueguen, C. Vaquette, M. Salga, W. Fleming, B. Jose, S. Millard, A. Pettit, K. Schroder, G. Thomas, L. Wheeler, F. Genet, S. Banzet, , J.-P. Levesque

This study shows IL-1 signaling promotes neurogenic heterotopic ossification in mice and humans by activating fibro-adipogenic progenitors.

bioRxiv · Oct 19, 2021Physiology

Relationship between epicardial and perivascular fatty tissue and adipokine-cytokine level in coronary artery disease patients

O. Gruzdeva, E. Uchasova, Y. Dyleva, D. Borodkina, O. Akbasheva, V. Karetnikova, N. Brel, K. Alexander, O. Barbarash

This study examines the relationship between epicardial and perivascular fatty tissue thickness and adipokine-cytokine levels in coronary artery disease patients, finding EAT and PVAT as independent risk factors and potential drug effectiveness models.

bioRxiv · Nov 14, 2018Biochemistry