Gut Microbes and the Liver Circadian Clock Partition Glucose and Lipid Metabolism
K. Frazier, S. Manzoor, K. Carroll, O. DeLeon, S. Miyoshi, J. Miyoshi, M. St George, A. Tan, M. Izumo, J. S. Takahashi, M. C. Rao, V. A. Leone, E. B. Chang
This study shows the liver circadian clock and gut microbes interact to regulate glucose and lipid metabolism in mice, with the liver clock driving rhythmic gene expression and gut microbes providing secondary cues when the liver clock is dysfunctional.
bioRxiv · May 24, 2022 · PreprintPhysiology