V. Leone

HMGB1 acts as an agent of host defense at the gut mucosal barrier

This study identifies HMGB1 as a host defense molecule in the gut mucosal barrier that targets bacterial adhesins to prevent microbial invasion and adhesion.

Autoregulation of a trimeric transporter involves the cytoplasmic domains of both adjacent subunits

This study uses molecular simulations to analyze the autoregulatory domains of BetP, showing how C-terminal tails interact with neighboring subunits and how N-terminal tails may also contribute to regulation.

Osmotic stress response in BetP: How lipids and K+ team up to overcome downregulation

This study investigates how K+ and lipids regulate BetP's osmotic stress response by analyzing structural changes and K+ interactions in BetP.

Early-life microbial intervention reduces colitis risk promoted by antibiotic-induced gut dysbiosis

The paper shows that adding a specific Bacteroides strain early in life reduces colitis risk in genetically susceptible mice with antibiotic-induced gut dysbiosis.

Chloride-dependent conformational changes in the GlyT1 glycine transporter

This study investigates how chloride ions influence conformational changes in the GlyT1 glycine transporter by analyzing ligand binding and structural shifts in response to ions and substrates.

High fat diet disrupts diurnal interactions between REG3g and small intestinal gut microbes resulting in metabolic dysfunction

Phenylpropionc acid produced by gut microbiota alleviates acetaminophen-induced hepatotoxicity

This study shows that phenylpropionic acid from gut microbiota reduces acetaminophen-induced liver damage in mice by inhibiting the toxic enzyme CYP2E1.

Metagenomic alterations in gut microbiota precede and predict onset of colitis in the IL10 gene-deficient murine model

The paper examines gut microbiota metagenomic profiles in a murine model to predict colitis onset and finds functional subsystems, particularly nitrogen metabolism, differ between mice that develop colitis and those that do not.

Development of early-stage type 1 diabetes in germ-free interleukin-10 deficient mice

This study shows that germ-free IL-10 deficient mice develop early pancreatic lymphocytic infiltration and insulin autoantibodies, suggesting gut microbiota protect against T1D pathogenesis.

Assignment of the resting state of the secondary active transporter BetP by integrating spectroscopic measurements and molecular simulations

The paper assigns the resting state of BetP by integrating spectroscopic measurements and molecular simulations to clarify its transport mechanism.