Author

O. DeLeon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:metagenomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

E. B. Chang· 2 shared J. Miyoshi· 2 shared S. Miyoshi· 2 shared V. A. Leone· 2 shared A. Fiebig· 1 shared A. M. Deutschbauer· 1 shared A. M. Sidebottom· 1 shared A. Tan· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersPhysiology

E. B. Chang

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Imbalanced gut microbiota predicts and drives the progression of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in a fast-food diet mouse model

N. Fei, S. Miyoshi, J. B. Hermanson, J. Miyoshi, B. Xie, O. DeLeon, M. Hawkins, W. Charlton, M. D'Souza, J. Hart, D. Sulakhe, K. B. Martinez-Guryn, E. B. Chang, M. R. Charlton, V. A. Leone

The paper shows fast-food diets cause gut microbiota imbalances that predict and drive NAFLD progression in mice, with effects seen in conventionally-raised but not germ-free mice.

bioRxiv · Jan 9, 2023 · PreprintPhysiology

Gut Microbes and the Liver Circadian Clock Partition Glucose and Lipid Metabolism

K. Frazier, S. Manzoor, K. Carroll, O. DeLeon, S. Miyoshi, J. Miyoshi, M. St George, A. Tan, M. Izumo, J. S. Takahashi, M. C. Rao, V. A. Leone, E. B. Chang

This study shows the liver circadian clock and gut microbes interact to regulate glucose and lipid metabolism in mice, with the liver clock driving rhythmic gene expression and gut microbes providing secondary cues when the liver clock is dysfunctional.

bioRxiv · May 24, 2022 · PreprintPhysiology

Dynamic genetic adaptation of Bacteroides thetaiotaomicron murine gut colonization

M. Zhang, M. Kennedy, O. DeLeon, J. Bissell, F. Trigodet, K. Lolans, S. Temelkova, K. T. Carroll, A. Fiebig, A. M. Deutschbauer, A. M. Sidebottom, C. S. Henry, P. A. Rice, J. Bergelson, E. Chang

This study tracks genetic and metabolic changes in Bacteroides thetaiotaomicron during gut colonization, showing shifting gene usage and highlighting the importance of carbohydrate metabolism for long-term persistence.

bioRxiv · Feb 23, 2022 · PreprintMicrobiology