E. B. Chang

Microbiota-dependent early life programming of gastrointestinal motility

This study shows that early life microbiota exposure shapes adult gastrointestinal motility by influencing enteric nervous system development.

Untangling the Role of Pathobionts from Bacteroides Species in Inflammatory Bowel Diseases

This study shows that Bacteroides fragilis from UC patients promotes colitis in genetically susceptible mice, suggesting a role for pathobionts in IBD.

A highly conserved and globally prevalent cryptic plasmid is among the most numerous mobile genetic elements in the human gut

The paper identifies a highly prevalent cryptic plasmid in the human gut that is more numerous than crAssphage and has potential applications in detecting fecal contamination and inflammatory states.

Imbalanced gut microbiota predicts and drives the progression of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in a fast-food diet mouse model

The paper shows fast-food diets cause gut microbiota imbalances that predict and drive NAFLD progression in mice, with effects seen in conventionally-raised but not germ-free mice.

Intestinal Epithelial Heat Shock Protein 25/27 integrates host and microbial drivers of mucosal restitution following inflammatory injury

This study identifies Hsp25/27 as a key mediator of mucosal healing by integrating host and microbial signals in intestinal epithelial cells following inflammatory injury.

Gut Microbes and the Liver Circadian Clock Partition Glucose and Lipid Metabolism

This study shows the liver circadian clock and gut microbes interact to regulate glucose and lipid metabolism in mice, with the liver clock driving rhythmic gene expression and gut microbes providing secondary cues when the liver clock is dysfunctional.

Early-life microbial intervention reduces colitis risk promoted by antibiotic-induced gut dysbiosis

The paper shows that adding a specific Bacteroides strain early in life reduces colitis risk in genetically susceptible mice with antibiotic-induced gut dysbiosis.

Nanotraps for the containment and clearance of SARS-CoV-2

This paper introduces Nanotraps, functionalized nanoparticles that block SARS-CoV-2 infection by inhibiting spike protein-ACE2 interaction and triggering macrophage-mediated viral clearance.

A Neutralizing Antibody-Conjugated Photothermal Nanoparticle Captures and Inactivates SARS-CoV-2

This paper develops a photothermal nanoparticle conjugated with neutralizing antibodies to capture and inactivate SARS-CoV-2, showing efficient viral capture, photothermal effect, and inhibition of viral entry.

High fat diet disrupts diurnal interactions between REG3g and small intestinal gut microbes resulting in metabolic dysfunction

Phenylpropionc acid produced by gut microbiota alleviates acetaminophen-induced hepatotoxicity

This study shows that phenylpropionic acid from gut microbiota reduces acetaminophen-induced liver damage in mice by inhibiting the toxic enzyme CYP2E1.

Metagenomic alterations in gut microbiota precede and predict onset of colitis in the IL10 gene-deficient murine model

The paper examines gut microbiota metagenomic profiles in a murine model to predict colitis onset and finds functional subsystems, particularly nitrogen metabolism, differ between mice that develop colitis and those that do not.

Development of early-stage type 1 diabetes in germ-free interleukin-10 deficient mice

This study shows that germ-free IL-10 deficient mice develop early pancreatic lymphocytic infiltration and insulin autoantibodies, suggesting gut microbiota protect against T1D pathogenesis.

High-throughput isolation and sorting of gut microbes reduce biases of traditional cultivation strategies

This study develops a microfluidic platform to isolate and sort gut microbes, increasing richness and rare taxa representation compared to traditional methods.

Mice Lacking FXR Are Susceptible to Liver Ischemia-Reperfusion Injury

This study shows that FXR deficiency increases liver damage and inflammation during ischemia-reperfusion injury, with altered bile acid metabolism and gut microbiota composition.